A Study of Basic Clinical Characteristics of Patients with Long-term HEV IgM Antibody Positive
Objective To evaluate the basic clinical characteristics of patients with long-term IgM antibody positive.Methods We retrospectively analyzed patients who underwent hepatitis E antibody and/or nucleic acid testing from January,2018 to September,2023 at Beijing You'an Hospital affiliated with Capital Medical University(a hospital with infection,infection,and acute and chronic related diseases as the main service target and key disciplines).We conducted the analysis to better understand the incidence of hepatitis E infection in the population receiving specialized treatment for infection and/or liver disease.Clinical characteristics were compare between the group(A)whose HEV IgM positive duration was greater than 6 months and those(B)whose HEV IgM turned into negative within 6 months.Results In the past six years(from January 2018 to September 2023),there were a total of 31,912 patients who underwent IgM and IgG antibody testing for hepatitis E in Beijing You'an Hospital.The positive rate of HEV IgM was 6.92％(2 280/31912)and the positive rate of HEV IgG was 24.36％(7 775/31 912).HEV IgM positivity rates of these years were statistically significant(X2=114.723,P＜0.001).But there was no statistically significant difference among 2018,2019 and 2023,with an average HEV IgM positivity rate of 5.66％.According to the antibody test results,patients were divided into four groups:IgM+IgG+group,IgM+IgG-group,IgM-IgG+group,and IgM-IgG-group.The difference in the positive rate of hepatitis E nucleic acid among the four groups was statistically significant(X2=232.791,P＜0.001).The IgM+IgG+group and IgM+IgG-group had higher nucleic acid detection rates and positive nucleic acid rates.When compared group A with group B,we found that the baseline ALT,TBil and DBil of the first visit in group A were significantly lower than group B(all P＜0.05).TP was higher than group B(P＜0.05).Conclusion In recent years,the infection rate of hepatitis E among patients in key departments of hepatitis E has been relatively stable.The basic clinical characteristics of hepatitis E patients with long-term persistent HEV IgM positive are featured with lower levels of ALT,TBil and DBil,while TP is higher than ordinary hepatitis E patients at the first visit.
Hepatitis E virusIgM antibodyIgG antibodyHEV RNALong-term
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