The Relationship Between Hyperandrogenemia and Coagulation Function in Polycystic Ovary Syndrome
Objective To investigate the influence factors of hyperandrogenemia in patients with polycystic ovary syndrome(PCOS)and the relationship between hyperandrogenemia and coagulation index.Methods The general data of 274 patients with PCOS were collected,while multiple endocrine-related indexes(FSH,LH,AMH,androgen),metabolic indexes(fasting blood glucose,insulin),and coagulation-related indexes(FIB,PT,INR,PA,TT,APTT,D-Dimer,PLT)were measured.The influencing factors of hyperandrogenism in this study cohort were explored by univariate analysis and logistics regression analysis,and the potential relationship between hyperandrogenism and coagulation indexes was further analyzed.Results The proportion of 274 PCOS patients with hyperandrogenemia was 52.55％(144/274)and the proportion of non-hyperandrogenemia was 47.45％(130/274).There were no significant differences in age,distribution ratio of overweight or obesity and AMH,PT,INR,PA,TT and APTT between the two groups(P＞0.05).Oligomenorrhea,LH/FSH≥2.5,distribution ratio of insulin resistance,FIB,D-Dimer and PLT in hyperandrogenemia group were significantly higher than those in non-hyperandrogenemia group(P＜0.05).Logistics regression analysis suggested that oligomenorrhea,LH/FSH≥2.5 and FIB were independent risk factors for PCOS combined with hyperandrogenemia,with OR values of 2.286,3.105 and 1.615,respectively(P＜0.05).Conclusion Polycystic ovary syndrome has a higher probability of hyperandrogenemia,which is related to oligomenorrhea,endocrine and coagulation indexes.Hyperandrogenemia has a higher risk of coagulation than non-hyperandrogenemia.
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