An Analysis of Pan-cancer on the Relationship Between HOXA Gene Cluster Expression and Prognosis
Objective To investigate the expression of protein-coding genes and non-coding genes in HOXA gene cluster in pan-cancer and to evaluate their roles in tumor prognosis.Methods The composition and mutual positional relationship of protein-coding and non-coding genes and the sequence conservation HOXA gene cluster were analyzed.Based on the UALCAN analysis website for cancer omics data,expression patterns of 11 HOXA-coding and 6 non-coding genes transcribed by the HOXA gene cluster in 24 cancers were assessed,and Kaplan-Meier analysis was performed to evaluate the correlation between protein-coding and non-coding gene expression in the HOXA gene cluster and tumor prognosis in pan-cancers.Results The human HOXA gene cluster consisted of 11 protein-coding genes and 6 annotated non-coding genes,which were located on the negative and positive strands of DNA on chromosome 7p15.2.The results from the current study showed that the expression of protein-coding and non-coding genes transcribed by HOXA gene cluster was different from that in normal control tissues,and the expression pattern was tissue-specific.Low expression of protein-coding and non-coding genes in the HOXA gene cluster was associated with a better prognosis of 9 types of cancers.Conclusion HOXA gene cluster members could be important molecular biomarkers for the diagnosis and prognosis of pan-cancer.
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