An Analysis of Pathogenic Bacteria Distribution and Drug Resistance in Psoriasis Vulgaris Patients with Bacterial Infection
Objective To investigate major components of pathogenic bacteria distribution and antibiotic resistance of psoriasis vulgaris patients with bacterial infection,so as to guide the clinical rational use of antibiotics.Methods A total of 154 secretions from skin lesions of psoriasis vulgaris patients who were hospitalized in the Department of Dermatology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from January,2021 to December,2023 were selected as the study subjects.The isolated strains were identified and tested by VITEK 2 compact automatic microbial identification and drug sensitivity analysis system.The characteristic distributions of pathogenic bacteria and drug susceptibility test results were analyzed.Results A total of 154 strains of pathogenic bacteria were isolated from psoriasis vulgaris patients with skin infection,of which 78.57％ were Gram-positive bacteria,while 19.48％ were Gram-negative bacteria. The main separated strains were Staphylococcus aureus,Staphylococcus epidermis,Staphylococcus haemolyticus and Pseudomonas aeruginosa.The resistance rate of Staphylococcus aureus to penicillin was 80.82％,while the resistance rate of Staphylococcus epidermidis to penicillin and levofloxacin were 86.96％ and 73.91％,respectively,and the resistance rate of staphylococcus hemolyticus to ciprofloxacin,levofloxacin and penicillin was 100％.Pseudomonas aeruginosa showed no resistance to quinolones,aminoglycosides,carbapenems and cephalosporins.The detection rate of methicillin-resistant Staphylococcus aureus(MRSA)in 73 strains of Staphylococcus aureus was 10.96％.Conclusion Gram-positive bacteria,especially Staphylococcus aureus and Staphylococcus epidermidis,are the main pathogenic bacteria of psoriasis vulgaris patients with bacterial infection,and the resistance rate to penicillin and levofloxacin is high,generally accompanied by a certain proportion of MRSA infection.
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