血清甲基乙二醛在2型糖尿病及健康人中的相关因素分析
A Study of Relevant Factors Associated with Serum Methylglyoxal in Type 2 Diabetes Mellitus and Healthy Individuals
章诗琪 1张琴琴 1杨光 1唐明娜 1范玉莹 1崔迪1
作者信息
- 1. 安徽医科大学第一附属医院内分泌科,安徽 合肥 230032
- 折叠
摘要
目的 在2型糖尿病患者和健康人群中探究哪些因素会影响人体血液中MGO的浓度以及血清MGO与糖尿病慢性并发症的关系,以评估MGO在糖尿病发生发展中的临床价值.方法 本研究招募了375例2型糖尿病,伴有不同程度的糖尿病慢性并发症和128例健康对照者,收集患者的临床资料.进行单因素和多因素回归分析,以确定血清MGO浓度的相关因素.结果 在所有受试者中:Log10(血清MGO+1)与BMI(r=0.2028,P<0.0001)、TG(r=0.1992,P<0.0001)显著正相关,与血红蛋白(r=-0.0936,P=0.0358)、TC(r=-0.0660,P=0.1395)呈负相关;在健康受试者中Log10(血清MGO+1)与eGFR(r=0.3664,P<0.0001)、BMI(r=0.2834,P=0.0012)呈显著正相关;在糖尿病患者中,Log10(血清MGO+1)仅与BMI相关(r=0.156,P<0.05).结论 在所有受试者中,BMI、三酰甘油、血红蛋白和总胆固醇影响血清MGO浓度;健康人中BMI、eGFR影响血清MGO浓度;糖尿病患者的血清MGO浓度仅受BMI影响.
Abstract
Objective This study aims to delineate the relevant factors to the serum MGO concentration in type 2 diabetic patients and healthy individuals,so as to evaluate the clinical value of MGO in the development of diabetes.Methods A total of 503 subjects including 375 type 2 diabetic patients and 128 healthy individuals were recruited for this study.Both demographic and clinical data of these subjects were collected.Results Log10(serum MGO+1)was positively correlated with body mass index(BMI)(r=0.2028,P<0.05)and triglyceride(r=0.1992,P<0.05),while negatively correlated with hemoglobin(r=-0.0936,P=0.0358)and serum total cholesterol(r=-0.0660,P=0.1395)in all subjects.In healthy subjects,a significant correlation was also observed between log10 (serum MGO+1)and eGFR(r=0.3664,P<0.05)and BMI(r=0.2834,P=0.0012).Log10 (serum MGO+1)was relevant to BMI in diabetic patients(r=0.156,P<0.05).Conclusion Serum MGO concentration is affected by BMI,triglyceride,hemoglobin and total cholesterol in all subjects,and is affected by BMI and eGFR in healthy subjects,while only affected by BMI in diabetic patients.
关键词
甲基乙二醛/2型糖尿病/糖尿病并发症Key words
Methylglyoxal/T2DM/Diabetic complications引用本文复制引用
基金项目
国家自然科学基金青年基金(81900746)
出版年
2024
NETL
NSTL
万方数据