Expressions of Blood Inflammatory Markers and PSA in Patients with Benign Prostatic Hyperplasia
Objective To detect expressions of C-reactive protein (CRP),high sensitive C-reaction protein (hs-CRP),Interleukin-6(IL-6),Salivary gland amylase A (SAA),White blood cell count (WBC),total prostate specific antigen(TPSA)and free prostate specific antigen (FPSA)in blood samples of patients with simple benign prostatic hyperplasia (BPH)and BPH combined with prostatitis,and to further evaluate the effect of inflammation on the development and progression of BPH.Methods 134 patients with prostatic hyperplasia from June,2022 to August,2023 in our hospital were collected as study group,and these patients were divided into a simple group and an inflammation group according to whether there was histological inflammation based on pathological check results.Fifty healthy men were also selected as the control group. Levels of serum CRP,hs-CRP,IL-6,SAA,TPSA,FPSA,white blood cell count and prostate volume (PV)were compared among the three groups.Spearman method was used to analyze associations between PV and CRP,hs-CRP,IL-6,SAA,WBC count,TPSA,and FPSA,as well as TPSA and CRP,hs-CRP,IL-6,SAA,WBC count,FPSA in BPH patients.Results Compared with the control group,PV of the simple BPH patients and the inflammation BPH patients increased,and levels of CRP,hs-CRP,IL-6,SAA,TPSA and FPSA increased significantly (P<0.01).Compared with simple BPH patients,PV volume of BPH patients with inflammation was increased,and levels of TPSA,FPSA,CRP,hs-CRP,SAA and IL-6 were also significantly increased(P<0.01).However,there was no significant difference in WBC among the three groups (P>0.05).Levels of CRP,hs-CRP,IL-6,SAA,WBC,TPSA and FPSA were positively correlated with PV in BPH patients(P<0.01).CRP,hs-CRP,IL-6,SAA and FPSA were positively correlated with TPSA(P<0.01).Conclusion Levels of CRP,hs-CRP,IL-6,SAA,TPSA and FPSA are significantly different among the three groups,and positively correlated with PV in BPH patients,which could play an important role in the development and progression of prostatic hyperplasia.As a key predictor of the occurrence of benign prostatic hyperplasia,further study is needed.
Prostatic hyperplasiaHistological inflammationProstate specific antigenInterleukin-6
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