A Study on Chromosomal Translocation and Adverse Pregnancy Events in Handan Area
Objective To explore the relationship between chromosomaltranslocation and adverse pregnancy events in Handan area.Methods A retrospective analysis was performed in 8,960 patients who visited Handan Central Hospital for genetic counseling from August,2011 to August,2023. Lymphocyte culture was performed on peripheral blood samples of these patients,and chromosome samples were prepared after harvesting for chromosome karyotype analysis.79 patients with confirmed chromosomal transmutation were selected as the observation group,while 79 patients with normal karyotype were randomly selected as the control group.The differences between the two groups and adverse pregnancy events were evaluated.Results Among 8960 genetic counseling patients,79 cases of chromosomal translocations were detected,with an abnormal rate of 0.88％,including 56 cases of balanced translocations (70.89％)and 23 cases of Robertson translocations (29.11％).The probability of spontaneous abortion,embryo termination,birth defect and infertility in the observation group was significantly higher than that in the control group (P<0.05),and the probability of no adverse pregnancy events in the control group was significantly higher than that in the observation group (P<0.05).Conclusion Chromosomal translocation is one of the important leading factors that can affect spontaneous abortion,embryo termination,birth defect,and infertility.It is of great significance to conduct chromosomal examination and assisted reproduction in the early stage of couples with adverse pregnancy events.
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