Expressions of NGAL and HMW-ADP in Pregnant Women with Pregnancy-induced Hypertension Syndrome and Their Correlations with Secondary Preeclampsia
Objective To investigate expressions of NGAL and HMW-ADP in pregnant women with pregnancy-induced hypertension syndrome and their relationships with secondary preeclampsia.Methods 129 patients with gestational hypertension syndrome admitted to the Obstetrics Department of our hospital from June,2021 to August,2023 were selected as the gestational hypertension syndrome group,including 51 cases of secondary preeclampsia and 78 cases of non-secondary preeclampsia.120 pregnant women with normal pregnancy during the same period were selected as the healthy pregnant women group.Serum levels of NGAL and HMW-ADP were compared between the two groups and pregnant women with secondary preeclampsia and non-secondary preeclampsia.The relevant data of pregnant women with secondary preeclampsia and non-secondary preeclampsia were also compared.Logistic regression analysis was performed to identify influencing factors of preeclampsia secondary to pregnancy-induced hypertension syndrome.Receiver operating characteristics (ROC)curves were drawn to evaluate the predictive value of serum NGAL and HMV-ADP levels for secondary preeclampsia in patients with pregnancy-induced hypertension syndrome.Results Compared with the healthy pregnant women group,the serum level of NGAL in the pregnancy-induced hypertension syndrome group was significantly increased (P<0.05),while the level of HMW-ADP was significantly decreased (P<0.05).Compared with non-pre-eclampsia pregnant women,the serum NGAL level was significantly increased (P<0.05),while the serum HMW-ADP level was significantly decreased (P<0.05).There were significant differences in gestational diabetes mellitus,family history of preeclampsia,uric acid,24h urinary protein,hematoma,TG,TC and LDL-C between non-secondary preeclampsia and secondary preeclampsia (P<0.05).Combined with gestational diabetes mellitus,family history of preeclampsia,24h urinary protein quantity,uric acid,LDL-C and NGAL were the risk factors for secondary preeclampsia of pregnancy-induced hypertension syndrome (P<0.05),while HMW-ADP was the protective factor (P<0.05).AUC values of serum NGAL and HMW-ADP for the detection of secondary preeclampsia alone were 0.833 and 0.887,respectively,while the AUC value of NGAL combined with HMW-ADP for detection of secondary preeclampsia was 0.936.The AUC value of NGAL combined with HMW-ADP was significantly higher than that of serum NGAL and HMW-ADP alone (Z=3.016,3.682,P<0.05).Conclusion The increase of serum NGAL level and the decrease of HMW-ADP level in patients with pregnancy-induced hypertension syndrome are the influencing factors for the secondary preeclampsia.The combined detection of NGAL and HMW-ADP level has certain diagnostic efficacy for the secondary preeclampsia.
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