An Analysis of the Maximum Immunity to Interference for D-dimer Endogenous Interferences in Different Detection Systems
Objective To investigate and evaluate the post-experimental results of the maximum acceptable interferent concentration for D-dimer detection noted by different detection systems.Methods We randomly collected 50 patient samples,then used four interferon of SYSMEX interferon detection kit,including bilirubin F,bilirubin C,hemolyzed hemoglobin,and chyle,for patient plasma diluted at a certain ratio.The concentration of interferon contained in the plasma after dilution and the reagent manual of the two detection systems indicating the maximum concentration of anti-interferon was close in two testing systems,respectively.Results When the concentration of the interfering substance bilirubin F reached the anti-interference Max concentration of D-dimer HS and AcuSTAR D-dimer,the percentage of results with relative deviation of<10％ were 26％ and 46％,respectively;When the concentration of the interfering substance bilirubin C reached the anti-interference Max concentration of D-dimer HS and AcuSTAR D-dimer,the percentage of results with relative deviation of<10％ were 18％ and 86％,respectively;When the concentration of the interfering substance hemolyzed hemoglobin reached the anti-interference Max concentration of D-dimer HS and AcuSTAR D-dimer,the percentage of results with relative deviation of<10％ were 44％ and 88％,respectively;When the concentration of the interfering substance chyle reached the anti-interference Max concentration of D-dimer HS and AcuSTAR D-dimer,the percentage of results with relative deviation of<10％ were 30％ and 58％,respectively.Conclusion Chemiluminescence is more resistant to high concentrations of endogenous interfering substances than immunoturbidimetric assay in the detection of D-dimer.
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