HBV感染是我国最主要的传染性疾病之一,目前临床主要使用体外诊断试剂对该病毒进行准确快速的检测,体外诊断试剂盒的方法学主要包括:免疫学方法和分子生物学方法.本文通过PubMed(检索时限自2017年1月至2023年12月)和万方数据库(检索时限自2017年1月至2023年12月)检索乙型肝炎病毒(hepatitis B virus,HBV)的检测方法、相关试剂盒的生产和临床应用的相关文献,详细列举最新检测方法的进展并比较不同方法学的优缺点,全面分析和讨论了我国目前乙型肝炎病毒检测的现状和研究进展.研究发现,我国HBV检测用商品化试剂盒的方法学分布存在集中现象,试剂盒的生产存在"东部多,西部少,大分散,小聚集"的特点.
The Research on the Current Status of Hepatitis B Virus Detection Methods
HBV infection is one of the main infectious diseases in China,and in current clinical practice,in vitro diagnostic reagents are mainly used for accurate and rapid detection of the virus.The methodology of in vitro diagnostic kits mainly includes immunological methods and molecular biology methods.We retrieved literatures through PubMed (search period from January,2017 to December,2023)and Wanfang database (search period from January,2017 to December,2023).We then summarized the latest research progress of detection methods,production of related test kits,and clinical applications of hepatitis B virus (HBV)in relevant literature.This article comprehensively summarizes and discusses the current status and research progress of hepatitis B virus detection in China by listing in details of the progress of the latest detection methods and comparing the advantages and disadvantages of different methods.Recent research has shown that the methodological distribution of commercialized HBV testing kits in China is concentrated,and the production of kits is characterized by a pattern as follows:more in the eastern region of China,while less in the western region of China;large dispersion,and small aggregation.
Hepatitis B virusDetection methodsConcentration phenomenon
NETL
NSTL
万方数据
