Study on the Correlation of Serum Urea,Hs-CRP,Homocysteine and Blood Lipid Levels with Carotid Plaque Stability and Stenosis
Objective To investigate the correlation of different serum indicators with carotid plaque stability and stenosis.Methods The study was conducted on 476 carotid plaque patients admitted to this hospital from November 2021 to November 2022 were retrospectively analyzed.According to carotid ultrasound,the patients were divided into stable plaque group(81 cases)and unstable plaque group(395 cases).The degree of carotid stenosis was divided into mild stenosis group(111 cases),moderate stenosis group(245 cases)and severe stenosis group(120 cases).The general data and different serum indicators were compared among different groups.The receive operating characteristic(ROC)was used to evaluate the serum indicators on admission and the predictive value of the occurrence of unstable carotid plaque in patients.Spearman was used to analyze the correlation between the serum indicators and severity of carotid stenosis.Results The vulnerable plaque group had higher Urea,hs-CRP and Hcy,but lower Apo A and HDL-C when compared with the stable plaque group(all P＜0.05).The levels of Apo A and HDL-C in the mild stenosis group were significantly higher than those in the moderate and severe stenosis groups.The levels of Urea,hs-CRP and Hcy in the severe stenosis group were higher than those in the mild and moderate stenosis group(all P＜0.05).Receive operating characteristic(ROC)curve analysis indicated that the area under the curve(AUC)of Urea,Apo A,HDL-C,hs-CRP and Hcy for diagnosis plaque stability was 0.822,the specificity was 85.5％,and the sensitivity was 75.2％.Spearman correlation analysis suggested that Urea,hs-CRP and Hcy were positively correlated with the severity of carotid stenosis,but Apo A and HDL-C were negatively(P＜0.05).Conclusion The levels of Urea,Apo A,HDL-C,hs-CRP and Hcy are related to the occurrence of carotid plaque stability and stenosis.
UreaC-reactive proteinHomocysteineApoplipoprotein AHigh density lipoprotein cholesterolCarotid vulnerable plaqueCarotid stenosis
NETL
NSTL
万方数据
