The Investigation of the Effect of Doxycycline on Eradication of Helicobacter Pylori
Objective To investigate the role of doxycycline in Helicobacter Pylori eradication therapy.Methods A total of 120 Helicobacter Pylori positive patients were enrolled and randomly divided into 3 study groups,all of which received quadruple therapy.Rabeprazole enteric-coated capsule 20mg,bismuth potassium citrate capsule 0.6g,amoxicillin capsule 1g,and oral treatment twice a day were given to all three groups.The treatment group(Group A),with 40 cases,also received doxycycline hydrochloride tablet 1g,twice a day with oral treatment,while the control group(Group B),with 40 cases,also received clarithromycin disperse tablet 0.5g,twice a day with oral treatment and the other control group(Group C),with 40 cases,also received levofloxacin tablet 0.5g,once a day with oral treatment;The treatment duration of each group was 2 weeks.The eradication rate of Helicobacter Pylori and the incidence of adverse reactions were compared among all three groups.Results There was no significant difference in Helicobacter Pylori eradication rate between the treatment group and the control group(P＞0.05).There was no significant difference in the incidence of adverse reactions among all three groups(P＞0.05).Conclusion For Helicobacter Pylori eradication therapy,doxycycline can play an equivalent role with other antibiotics in quadruple regimens,and is more acceptable to patients.This approach can be used as a novel Helicobacter Pylori eradication treatment.
NETL
NSTL
万方数据
