A Study of the Application of DNA Ploidy Analysis and Liquid-based Cytology Detection to Divert the Infection of High-risk HPV in Cervical Lesions
Objective To investigate the value of DNA ploidy analysis and TCT detection in patients with cervical lesions infected by high-risk HPV.Methods A retrospective analysis was conducted among 182 patients infected with high-risk HPV in Nanjing University Medical School affiliated Suzhou Hospital from January,2022 to August,2023.According to the pathological diagnosis criteria of cervical biopsy,we observed and compared the detection results of DNA ploidy analysis and TCT in cervical lesions.Results Among 182 cervical biopsies samples,84 had chronic inflammation or HPV infection,while 69 had LSIL,and 29 had HSIL or more serious lesions(2 cases of squamous cell carcinoma).The positive rates of DNA ploidy analysis and TCT≥ASCUS were 78.02％(142/182)and 57.14％(104/182),respectively.There was no significant difference between them(P＞0.05).Among different levels of cervical lesions,the positive rates of DNA ploidy analysis results were significantly higher than those of TCT ≥ LSIL,and also higher than TCT≥ASCUS in patients with chronic inflammation or HPV infection(all P＜0.05).Based on the biopsy pathological diagnosis result,the specificity of TCT was 72.62％(61/84)and the Kappa value was 0.556,both of which were higher than the specificity of DNA ploidy analysis,which was 28.57％(24/84)and the Kappa value was 0.127.Conclusion In the diversion of cervical HPV infection,the diagnostic validity of TCT is better than that of DNA ploidy analysis,and the combined detection of these two methods has a better diversion ability and diagnostic value.
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