A Correlation Analysis Between PAI-1 and Hcy Levels and Pregnancy Outcomes in Pregnant Women with Heart Disease
Objective To explore the correlation between levels of plasminogen activator inhibitor-1(PAI-1)and homocysteine(Hcy)and the pregnancy outcomes of pregnant women with heart disease.Methods 80 pregnant women with heart disease admitted to our hospital from January,2020 to January,2023 were selected as the study group,while 80 healthy pregnant women were selected as the control group.Levels of PAI-1 and Hcy between these two group were compared.Patients in the study group were further divided into a poor pregnancy group(22 cases)and a good pregnancy group(58 cases)according to the pregnancy outcome.The clinical data,triglyceride(TG),total cholesterol(TC),PAI-1 and Hcy levels of the two groups were compared.The correlation was tested by Spearman rank correlation analysis.Multivariate analysis was conducted by binary logistics regression method;ROC curve was drawn to evaluate the value of serum PAI-1 and Hcy levels in predicting adverse pregnancy outcomes.Results Levels of PAI-1 and Hcy in the study group were significantly higher than those in the control group(P＜0.05).There was no significant difference in age,parity,gestational age,delivery gestational age,heart disease type,cardiac function classification,TC and TG between the poor pregnancy group and the good pregnancy group(P＞0.05).Levels of PAI-1 and Hcy in the poor pregnancy group were significantly higher than those in the good pregnancy group(P＜0.05).Levels of serum PAI-1 and Hcy in pregnant women with heart disease were positively correlated with the adverse pregnancy outcome(P＜0.05).Multivariate logistic regression analysis showed that PAI-1 and Hcy were significant influencing factors of adverse pregnancy outcome in pregnant women with heart disease.ROC curve showed that levels of PAI-1 and Hcy were able to predict the adverse pregnancy outcome of patients with pregnancy complicated with heart disease.The area under the curve were 0.810 and 0.817,respectively,while the area under the joint prediction curve was 0.918.Conclusion Levels of serum PAI-1 and Hcy in pregnant women with heart disease significantly increase the incidence of adverse pregnancy outcomes.These indexes are significantly related to adverse pregnancy outcomes,and their levels are the influencing factors,which can be used to predict adverse pregnancy outcomes,and the joint prediction value is higher than single-marker prediction.
Plasminogen activator inhibitor-1HomocysteinePregnancy complicated with heart diseasePregnancy outcomeCorrelation
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