足月妊娠孕妇血栓弹力图和Sonoclot凝血和血小板功能参考值范围及相关性的探讨
A Discussion of Reference Range and Correlation of Thromboelastogram and Sonoclot Coagulation and Platelet Function in Full-term Pregnancy
董林 1张媛 1徐菲 1包进 1蒋炎兴 1张帆1
作者信息
- 1. 南京医科大学附属南京医院/南京市第一医院医学检验科,江苏南京 210006
- 折叠
摘要
目的 建立健康足月妊娠孕妇血栓弹力图和Sonoclot凝血和血小板功能检测参考值范围.方法 选取入住我院产科无凝血系统疾病等情况的足月妊娠孕妇160例,通过血栓弹力图(TEG)和Sonoclot检测,统计分析R值、K值、Angle值、MA值以及ACT、CR、PF,建立其参考值范围.结果 160例足月妊娠孕妇的TEG和Sonoclot检测,至少一项超过厂商推荐参考值范围为异常,异常率TEG为71.70％,Sonoclot为56.87％.本研究中TEG指标的参考值范围:R3.4～7.9min,K0.9～3.0min,Angle 62.9～72.9°,MA 48.0～83.6mm;ACT 125.5～184.5s、CR 20.2～63.6clot/min、PF 0.6～4.7.在两种检测方法之间,所有检验指标间仅ACT与R值有相关性(P＜0.05).结论 妊娠期孕妇的凝血状态与非孕正常人群有着明显的差别,其厂商提供在TEG和Sonoclot凝血与血小板功能分析的参考值范围不适用于足月妊娠孕妇,需要重新建立这两个项目的参考值范围以便临床诊疗的准确进行.
Abstract
Objective To develop the reference range of thromboelastography and Sonoclot coagulation and platelet function in healthy full-term pregnant women.Methods 160 cases of full-term pregnant women admitted to the Obstetrics Department of our hospital without coagulation system diseases were selected for the study.The R value,K value,Angle value,MA value,ACT value,CR value and PF value of these subjects were statistically analyzed by means of thrombologram and Sonoclot detection results.The related reference value ranges were then established.Results In 160 cases of full-term pregnant women,at least one TEG and Sonoclot test exceeded the manufacturer's recommended reference value range which was considered as abnormal,and the abnormal rate of Sonoclot was 56.87％,For TEG,the rate was 71.70％.The reference values of TEG indexes ranged as follows:R3.4-7.9min,K0.9-3.0min,Angle 62.9-72.9°,and MA 48.0-83.6mm.ACT 125.5-184.5s,CR 20.2-63.6clot/min,and PF 0.6-4.7.Among the two detection methods,only ACT was correlated with R values(P＜0.05).Conclusion The coagulation status of pregnant women is significantly different from that of non-pregnant normal population.The reference value range of TEG and Sonoclot for coagulation and platelet function analysis provided by the manufacturer is not applicable to full-term pregnant women.The reference value range of these two items needs to be re-established for more accurate clinical diagnosis and treatment.
关键词
血栓弹力图/Sonoclot凝血与血小板功能/足月妊娠/参考值Key words
Thromboelastography/Sonoclot coagulation and platelet function/Full-term pregnancy/Reference value引用本文复制引用
基金项目
南京市卫生科技发展课题(YYK22107)
江苏省医学重点学科建设单位(JSDW202239)
出版年
2024
NETL
NSTL
万方数据