The Diagnostic Value of Serum CEA,NSE,SCC-Ag,and CA125 Combined Test in Non-small Cell Lung Cancer
Objective To explore the diagnostic value of a combined test of serum carcinoembryonic antigen(CEA),neural specific enolase(NSE),squamous cell carcinoma associated antigen(SCC-Ag),and carbohydrate antigen 125(CA125)in non-small cell lung cancer(NSCLC).Methods 110 NSCLC patients who visited our hospital from January,2021 to January,2024 were selected as the NSCLC group,while 50 healthy volunteers who underwent physical examinations at our hospital during the same period were selected as the control group.We identified and evaluated differences in serum CEA,NSE,SCC-Ag,and CA125 levels between these two groups;According to the pathological T stage,NSCLC patients were divided into three different subgroups:T1,T2,and T3.Based on the pathological N stage,NSCLC patients were divided into three different subgroups:N0,N1,and N2.The differences in serum CEA,NSE,SCC-Ag,and CA125 levels among NSCLC patients with different pathological T stages and N stages were identified and evaluated;ROC curves were drawn to analyze the effectiveness of single and combined indicators in the diagnosis of NSCLC.Results In comparison of CEA,NSE,SCC-Ag,and CA125 levels,the NSCLC group was higher than the control group(P＜0.05).Levels of serum CEA,NSE,SCC-Ag,and CA125 all increased with the increase of pathological T stage in NSCLC patients(P＜0.05),and the differences in results of each stage were statistically significant(P＜0.05).Levels of serum CEA,NSE,SCC-Ag,and CA125 all increased with the increase of pathological N-stage in NSCLC patients(P＜0.05),and the differences in results of each stage were statistically significant(P＜0.05).AUCs of CEA,NSE,SCC-Ag,and CA125 in diagnosing NSCLC were 0.869(95％CI,0.827-0.917),0.873(95％CI,0.812-0.921),0.854(95％CI,0.789-0.905),and 0.826(95％CI,0.758-0.881),respectively.AUC of four markers combined in diagnosing NSCLC was 0.982(95％CI,0.947-0.996),all of which were more effective than the single indicators of CEA,NSE,SCC-Ag,and CA125(Z=4.152,4.268,4.663,4.783,P＜0.001).Conclusion There is an association between serum CEA,NSE,SCC-Ag,CA125 and the pathological type,number of lymph node metastases,and EGFR genotype of NSCLC.Combined detection of CEA,NSE,SCC-Ag,and CA125 levels can effectively improve the clinical diagnostic efficiency of NSCLC.
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