The Investigation of Diverse Fibrinogen Detection Techniques Inthe Thrombolytic Procedure
Objective To investigate the application of different methods for fibrinogen(fibrinogen,Fib)detection in patients undergoing therapeutic thrombolysis.Methods A total of 78 patients admitted to our hospital from September,2021 to December,2023 for therapeutic thrombolysis were selected as the experimental group.All patients received urokinase treatment(43 cases with acute myocardial infarction thrombolysis and 35 cases with tumor radiotherapy thrombolysis),and Fib concentrations were measured by Clauss method,PT-derivative method,and immunoassay method after thrombolysis.The standardization range of Fib by Clauss method was 0.4-5.05g/L.Simultaneously,110 non-thrombolytic specimens were selected as the control group,and Fib was standardized by Clauss method into three intervals:＜1.6g/L interval represented the low level group with 30 cases;1.6-4.0g/L interval represented the medium level group with 40 cases;＞4.0g/L interval represented the high level group with 40 cases.Fib concentrations were measured by Clauss method,PT-derivative method,and immunoassay method in both groups to analyze the impact of thrombolysis on Fib concentration.Results In non-thrombolytic specimens,there was no statistical difference in Fib concentrations within＜1.6g/L and 1.6-4.0g/L intervals between Clauss method and PT-derivative/immunoassay methods(P＞0.05).Within＞4.0g/L range,there was no statistical difference(P＞0.05)between results obtained from PT-derivative/immunoassay methods in detecting Fib concentration;However,both methods yielded higher values than those obtained from Clauss method with a statistically significant difference(P＜0.05).In contrast,in the thrombolytic experimentgroup,no statistical difference(P＞0.05)was observed between the results obtained from PT-derived method and immunoassay method in detecting Fib concentration;However,both methods yielded higher values than those obtained from Clauss method with a statistically significant difference(P＜0.05).Conclusion During thrombolytic therapy,PT-derived method and immunoassay method are affected by the thrombolytic fragments,resulting in significantly higher Fib concentrations than Clauss method for detecting Fib function.Therefore,it is recommended to use Clauss method to detect Fib concentrations during thrombolytic therapy.
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