An Analysis of the Pathogen Spectrum and Drug Resistance of Infectious Diarrhea in Beijing Economic-Technological Development Area from 2021 to 2023
Objective To understand the common pathogenic bacteria species,epidemic trends,and drug resistance of infectious diarrhea patients in Beijing Economic-Technological Development Area,thereby providing a scientific basis for epidemiological research and clinical treatment in this region.Methods From January 1,2021 to December 31,2023,fecal samples from 6 902 patients with infectious diarrhea who visited the Gastrointestinal Clinic,Pediatrics,and Emergency Department of Beijing Tongren Hospital affiliated with Capital Medical University were collected for the sampling process including enrichment,isolation,and culture.Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS)was applied for bacterial species identification,while agglutination tests were used to determine serotypes,and the Kirby-Bauer disk diffusion method was used to determine antimicrobial susceptibility.Results Among the 6 902 samples,390 strains of pathogenic bacteria were detected,with an overall detection rate of 5.65％.Salmonella and Vibrio parahaemolyticus were the two most common pathogens,accounting for 32.14％and 28.32％of the 390 detected strains,respectively.Among the detected Salmonella species,the dominant serotype was Salmonella enteritidis.Of the 27 Vibrio cholerae strains,92.59％belonged to the non-O1/O139 serogroup,and there was an increasing trend in recent years.The differences in detection among different age groups and pathogens were statistically significant(P＜0.001),with the 21-30 and 31-40 age groups having the most patients with infectious diarrhea.Additionally,the 0-10,11-20,and＞60 age groups were mainly infected with Salmonella,while the rest were mainly infected with Vibrio parahaemolyticus.The differences in detection among different months and pathogens were statistically significant(P＜0.001),with enteropathogenic bacteria having the highest detection rate in July-August,and Salmonella peaking in June-July.Different pathogens showed differences in sensitivity to various antimicrobial drugs,with aminopenicillins exhibiting a high resistance.Monocyclic β-lactams,quinolones,and aminoglycosides had a higher sensitivity,and multi-drug resistance also occurred.Conclusion Vibrio and Salmonella are the main pathogens of infectious diarrhea in the Beijing Economic-Technological Development Area,and various pathogens have different drug resistance profiles.Therefore,it is necessary to closely monitor the status of pathogens of infectious diarrhea and their resistance to various antimicrobial drugs.
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