Epidemic Situation and Drug Sensitivity Analysis of Vaginitis Due to Saccharomyces Cerevisiae
Objective To explore the epidemiology of Saccharomyces cerevisiae vaginitis and drug sensitivity of Saccharomyces cerevisiae.Methods The samples of Saccharomyces cerevisiae were collected from outpatients whose specimen indicated that the funfus was positive.93 strains of funfi were collected from 91 patients.The fugus was initially identified by CHROMagar candida and the result was used for further analysis of epidemiology of fungi from vagina.Combined with two strains of Saccharomyces cerevisiae collected later,95 strains of fungi were collected in total for the study.Drug susceptibility test were performed using colonies from all strains and the results were analyzed.Four strains of Saccharomyces cerevisiae were finally identified by mass spectrograph.Results 93 specimens were collected from 91 outpatients.Among which,60(65.90％)strains were Candida albicans,17(18.70％)strains were Candida glabrata,4(4.40％)strains were Candida krusei,2(2.20％)strains were Saccharomyces cerevisiae and 4(4.40％)strains were atypical fungus.The sensitivity rates of candida isolated to miconazole,amphotericin B,itraconazole,voriconazole,5-flucytosine,ketoconazole,clotrimazole,fluconazole,and terbinafine were 40.66％,28.57％,10.99％,29.67％,25.27％,86.81％,41.76％and 45.05％,respectively.Drug susceptibility test of Saccharomyces cerevisiae showed that it was sensitive to miconzole,ketoconazole and 5-flucytosine.Conclusion Candida albicans remain as the main pathogens of VVC.The drug sensitivity is different between candida and Saccharomyces cerevisiae.Vaginitis due to Saccharomyces cerevisiae is not common in clinic but it is resistant to multiple types of drugs,which should be carefully monitored.
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