The Relationship Between REC,a Novel Biomarker of Wilson's Disease,Cognitive Function and TCM Syndrome Type in Wilson's Disease
Objective To investigate the correlation between traditional Chinese medicine(TCM)syndromes types,cognitive function as well as the novel serum biological marker relative exchangeable copper(REC)in WD patients.Methods Fifty-seven WD patients were classified into the following types:damp-heat intrinsic syndrome(DHIS),phlegm-stasis interassociation syndrome(PSIS)and liver-kidney yin deficiency syndrome(LKYDS).The Montreal Cognitive Assessment(MoCA)and the Alzheimer's Disease Assessment Scale-cognitive subscale(ADAS-cog)were administered to evaluate cognitive functions.Flame Atomic Absorption Spectrometry was utilized to determine and calculate serum REC levels.The cognitive functions and REC levels of WD patients with different TCM syndromes were assessed,while concurrent analyses were conducted for the correlation between cognitive function and REC with the TCM syndromes,as well as their diagnostic prediction capability for TCM syndromes.Results The REC and ADAS-cog scores of DHIS were significantly higher than those of PSIS and LKYDS(DHIS vs PSIS,REC:P=0.016,ADAS-cog:P=0.035;DHIS vs LKYDS,REC:P＜0.001,ADAS-cog:P=0.001);The MoCA score of DHIS was significantly lower than that of PSIS and LKYDS(DHIS vs PSIS,P=0.047;DHIS vs LKYDS,P=0.004);Compared with LKYDS,there was no significant difference in the REC,MoCA,and ADAS-cog scores between PSIS and LKYDS(all P＞0.05).Pearson correlation analysis showed that there was a negative correlation between REC and MoCA in all three groups of patients,while a positive correlation with ADAS-cog;REC had the highest diagnostic value in evaluating DHIS.Conclusion In addition to its practicality in WD diagnosis,REC can also be used to evaluate cognitive impairment(and severity)in WD.The evaluation of REC levels and cognitive functions has certain diagnostic reference value in assessing the primary TCM syndromes in WD.
Wilson's diseaseSyndrome differentiation and classificationCognitive functionRelatively exchangeable copper
万方数据
维普
