Exploring the Relationship Between Vitamin A and D Levels and the Severity and Clinical Outcome of Mycoplasma Pneumoniae Pneumonia in Children
Objective To investigate the relationship between vitamin A and D levels and the severity and clinical outcome of Mycoplasma Pneumoniae pneumonia in children.Methods We selected 92 cases of children with Mycoplasma Pneumoniae pneumonia from January,2022 to June,2023 in our hospital as a research group.During the same period,92 cases of healthy children from physical examination,matching with sex and age,were selected as the control group.We tested serum vitamin A,D content,and investigated their relationship with Mycoplasma Pneumoniae pneumonia children.According to the clinical outcome of children with Mycoplasma Pneumoniae pneumonia,the subjects were divided into two groups:an excellent outcome(n=66)and a poor group(n=26).The contents of vitamin A and D were compared,the factors affecting the clinical outcome of children were defined,and the predictive value of vitamin A and D content on the disease degree and clinical outcome of children with Mycoplasma Pneumoniae pneumonia were analyzed.Results Compared with the control group,vitamin A and D content in the study group decreased,while vitamin A and D deficiency rate increased(P＜0.05).Compared with children with mild disease,children with severe Mycoplasma Pneumoniae had decreased vitamin A and D content,while the rate of vitamin A and D deficiency increased(P＜0.05).Compared with the excellent outcome group,the poor group was younger,with 7d,severe illness,abnormal myocardial enzyme spectrum,pleural effusion,extrapulmonary complications,and increased laboratory indicators of CRP,D-D,and LDH levels(P＜0.05).Compared with before treatment,levels of serum vitamin A and D increased in both the poor and excellent conversion groups after treatment(P＜0.05),and the deficiency rates of vitamin A and D decreased,but the difference was not statistically significant(P＞0.05);Serum vitamin A and D levels in children with Mycoplasma Pneumoniae pneumonia in the poor conversion group were lower than those in the excellent conversion group before and after treatment,while the vitamin A and D deficiency rates before and after treatment were higher than those in the excellent conversion group(P＜0.05).The influences of multiple factors were identified,such as the degree of adverse clinical outcome,pleural effusion,extrapulmonary complications,laboratory indicators,vitamin A and vitamin D(P＜0.05).ROC curve showed that the combined diagnosis of vitamin A and D before treatment was more effective in diagnosing the severity of Mycoplasma Pneumoniae pneumonia in children than a single-item test(P＜0.05).ROC curve also showed that when predicted separately,the predictive efficiency of post treatment vitamin D was better than that of post treatment vitamin A,which was better than that of pre-treatment vitamin D and pre-treatment vitamin A;When combined diagnosis,the efficacy of pre-treatment vitamin A,D,and post treatment vitamin A,D combination in predicting clinical outcomes in children with Mycoplasma Pneumoniae pneumonia was better than any single-item prediction(P＜0.05).Conclusion The deficiency of serum vitamin A and D is related to the severity and clinical outcomes of children with Mycoplasma Pneumoniae pneumonia.Early prediction of clinical outcomes in children with Mycoplasma Pneumoniae pneumonia is highly effective,especially after treatment with vitamin D.
Vitamin AVitamin DMycoplasma Pneumoniae pneumonia in childrenDegree of illnessClinical outcome
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维普
