The Relationship Between Serum FKN,Copeptin and Immune Function and Clinical Condition of Neonatal Infective Pneumonia
Objective To investigate the relationship between serum irregular chemokine(FKN),Copeptin and immune function and clinical condition of neonatal children with infectious pneumonia.Methods 82 cases of neonatal infectious pneumonia diagnosed and treated in our hospital from October,2021 to October,2023 were included as the observation group.Serum samples were taken from all neonates at admission.Serum immunoglobulin levels were detected by Beckman automatic specific protein immunoanalyzer IMMAGE800.Serum inflammatory factors and serum FKN and Copeptin levels were detected by enzyme-related immunosorbent assay.Spearman correlation coefficient was used to analyze the relationship between detected levels and immune function and clinical condition.Results In the observation group,serum FKN,Copeptin,serum immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),C-reactive protein(CRP),interleukin 10(IL-10),procalcitonin(PCT),and interleukin 17(IL-17)were all higher than those of the control group(P＜0.05).The levels of serum FKN,Copeptin,IgM,IgA,IgG,CRP,IL-10,PCT and IL-17 among severe children were all higher than those of mild children(P＜0.05).Spearman correlation analysis showed that serum FKN and Copeptin levels were positively correlated with IgM,IgA,IgG,CRP,PCT,IL-10 and IL-17 levels(P＜0.05).Conclusion The serum levels of FKN and Copeptin in newborn children with infectious pneumonia are high,and their levels are positively correlated with the immune function and severity of the disease.Monitoring their levels is of great reference significance for the early assessment of the clinical condition and immune function of the children,so as to guide clinical treatment and improve the quality of life.
Neonatal infectious pneumoniaImmune functionState of the diseaseIrregular chemokinesSynpeptin
万方数据
维普
