An Analysis of Antibiotic Resistance Characteristics of Pseudomonas aeruginosa in Bloodstream Infections from 2019 to 2023
Objective To investigate the antibiotic resistance characteristics and to identify trends of Pseudomonas aeruginosa in patients with bloodstream infections.Methods A total of 158 strains of Pseudomonas aeruginosa isolated from blood cultures at Guangdong Provincial People's Hospital between January,2019 and December,2023 were collected for the study.Strain identification and antibiotic susceptibility tests were conducted using the VITEK MS and VITEK 2 Compact systems.The produced datasets were analyzed using SPSS 22.0 and Whonet 5.6 statistical softwares.Results From 2019 to 2023,a total of 4024 pathogenic strains were isolated from clinical blood cultures,with Pseudomonas aeruginosa accounting for 158 strains(3.93％).The detection rate of carbapenem-resistant Pseudomonas aeruginosa(CRPA)increased,with 30 CRPA strains identified,accounting for 18.99％of the total.The resistance rates of CRPA to imipenem,meropenem,aztreonam,and cefepime were 92.9％,78.6％,44.4％,and 32.1％,respectively.Additionally,CRPA exhibited significantly higher resistance rates to various types of antibiotics compared to carbapenem-sensitive Pseudomonas aeruginosa(CSPA)(P＜0.001).The age distribution of studied patients was concentrated in the group of over 60 years old,accounting for 50.00％,and primarily distributed in the Hematology Department,Intensive Care Unit(ICU),and Emergency ICU.Conclusion The antibiotic resistance of Pseudomonas aeruginosa in bloodstream infections has increased annually,particularly with a rise in the detection rate of CRPA,which can impact patient prognosis.Clinicians should select antibiotics rationally and implement effective measures to strengthen the monitoring and control programs of resistant bacteria.
Bloodstream infectionPseudomonas aeruginosaAntibiotic resistanceCarbapenemsAntibiotic susceptibility test
万方数据
维普
