Changes of Serum Periostin and sIL-2R Levels in Children with Bronchial Asthma Complicated with Mycoplasma Pneumoniae Infections and Their Correlations with Serum Inflammatory Factors and Lung Function
Objective To investigate changes of serum periostin and soluble interleukin-2 receptor(sIL-2R)levels in children with bronchial asthma complicated with Mycoplasma pneumoniae(MP)infections,and to further evaluate their correlations with serum inflammatory factors and lung function.Methods A total of 60 children with bronchial asthma combined with MP infections(infection group),children with simple bronchial asthma(asthma group)and healthy children(control group)who underwent physical examination during the same period were selected respectively from our hospital from September,2021 to September,2023.Enzyme linked immunosorbent assay(ELISA)method was applied to detect serum levels of Periostin and sIL-2R.Pearson correlation analysis was applied to evaluate the correlation between serum Periodin and sIL-2R levels with inflammatory factors and lung function in children with bronchial asthma complicated with MP infection.Results Serum levels of Periostin and sIL-2R in the infection group,asthma group,and control group were all decreased sequentially(P＜0.05).Levels of serum interferon(IFN)-y,IL-4,IL-8,and tumor necrosis factor(TNF)-α were decreased sequentially in the infection group,asthma group,and control group(P＜0.05).The forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC)in the infection and asthma groups were lower than those in the control group(P＜0.05).The maximum expiratory flow(PEF)of the infection group,asthma group,and control group were increased sequentially(P＜0.05).Serum levels of Periostin and sIL-2R in children with bronchial asthma complicated with MP infection were positively correlated with IFN-γ,IL-4,IL-8,and TNF-α levels,while negatively correlated with PEF(P＜0.05).Conclusion Children with bronchial asthma complicated with MP infection have higher levels of serum Periodin and sIL-2R,which can be closely related to serum inflammatory factors and lung function.
Bronchial asthmaMycoplasma pneumoniae infectionPeriostinSoluble interleukin-2 receptorInflammatory factorsLung function
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维普
