Clinical Distribution Characteristics and Drug Resistance of 269 Strains of Carbapenem-resistant Enterobacteriaceae in a Tertiary Hospital in Sichuan
Objective To identify the distribution characteristics and to analyze the drug resistance of carbapenem-resistant Enterobacteriaceae(CRE)in our hospital from 2017 to 2023,and to further provide evidences and references for nosocomial infection prevention and control,as well as clinical drug usage.Methods Carbapenem-resistant enterobacter(CRE)was isolated from specimens collected from clinical departments of our hospital.Siemens MicroScan WalkAway40 automatic microbial analyzer was utilized for bacterial identification and drug susceptibility test,and WHONET 5.6 software was used for statistical analysis.Results A total of 9307 strains of Enterobacteriaceae bacteria were isolated in our hospital from 2017 to 2023,including 269 strains of CRE,with a total detection rate of 2.9％.From 2017 to 2019,the detection rate of CRE showed a yearly increasing trend,while the detection rate began to decline from 2020.The 269 strains of CRE were mainly derived from sputum samples(128 strains,47.6％),sterile midstream urine samples(92 strains,34.2％),secretions samples(18 strains,6.7％)and blood samples(17 strains,6.3％).The proportion of CRE in the elderly group(＞65 years old)was much higher than that of the adult group(15-65 years old),the child group(29-14 years old)and the newborn group(0-28 days old).The main cases were from Urology Department(18.6％),ICU(14.5％),Respiratory Department(10.8％),Neurosurgery Department(7.8％),Nephrology Department(7.0％),and Burn and Plastic Department(7.0％).The top three CRE were Klebsiella pneumoniae(CR-KPN)(97 strains,36.1％),Escherichia coli(CR-ECO)(77 strains,28.6％)and Enterobacter cloacae(CR-ECL)(39,14.5％).The resistance rates of CR-KPN and CR-ECO to carbapenems and β-lactams were both above 89％.The resistance rates to tigecycline and amikacin were low as follows:CR-KPN(6.5％,18.3％)and CR-ECO(4.9％,10.7％).Conclusion CRE has a strong drug resistance.Tigecycline and amikacin are rare drugs with good performances in vitro antibacterial activity against CRE.Antibiotics should be used reasonably in clinic.The hospital should strengthen prevention and control strategies for key departments and at-risk populations.
Carbapenem-resistant EnterobacteriaceaeDrug resistanceAntibacterial drug
万方数据
维普
