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大连市健康体检女性人乳头瘤病毒感染情况

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目的 探讨大连地区女性人乳头瘤病毒(human papillomavirus,HPV)感染情况以及不同年龄段中HPV的分布特征,为宫颈病变预防、治疗、随访提供流行病学依据.方法 选取2022年7月至2024年7月在大连市第二人民医院和大连市中心医院进行健康体检并接受HPV基因型检测的女性为研究对象,使用商业试剂盒进行HPV基因型检测,分析HPV感染情况,比较不同年龄段之间HPV阳性率差异.结果 HPV总阳性率为15.48%,其中仅高危型感染阳性率为10.96%,仅低危型感染阳性率为3.13%,高低危型合并感染阳性率为1.39%.单一感染阳性率为12.44%,多重感染阳性率为3.03%.阳性率居前五位的基因型为HPV52、HPV81、HPV58、HPV1和HPV42.HPV阳性率在不同年龄段间的差异具有统计学意义(x2=34.301,P<0.001).不同年龄段之间HPV多重感染的阳性率差异具有统计学意义(x2=21.793,P<0.001).12 种 HPV 基因型(HPV11、16、18、31、33、39、51、52、53、56、81 和 82)的阳性率在不同年龄段间的差异均具有统计学意义(P<0.05).结论 大连地区健康女性HPV感染以高危型、单一感染为主,不同年龄层具有不同的HPV基因型分布特点,为大连地区制定HPV防控策略提供参考依据.
The Status of Human Papillomavirus Infections Among Health Examination Women in Dalian City
Objective To investigate the status of human papillomavirus(HPV)infections in women in Dalian city and the distribution characteristics of HPV in different age groups,and to further provide epidemiological evidences for the prevention,treatment and follow-up study of cervical lesions.Methods Women who underwent physical examinations and HPV genotype tests in The Second People's Hospital of Dalian and Dalian Municipal Central Hospital from July,2022 to July,2024 were selected as the study subjects.HPV genotype test was then performed with commercial kits.The HPV infection status was analyzed and the difference of HPV positive rate among different age groups was evaluated.Results The overall positive rate of HPV was 15.48%,among which the positive rate of high-risk HPV was only 10.96%,while the positive rate of low-risk HPV was only 3.13%,and the positive rate of high-low-risk co-infections was 1.39%.The positive rate was 12.44%for single infection and 3.03%for multiple infections.The top 5 positive genotypes were HPV52,HPV81,HPV58,HPV1 and HPV42.The positive rate of HPV was significantly different among different age groups(x2=34.301,P<0.001).There was significant difference in the positive rate of HPV multiple infections among different age groups(x2=21.793,P<0.001).The positive rates of 12 HPV genotypes(HPV11,16,18,31,33,39,51,52,53,56,81 and 82)were significantly different among different age groups(P<0.05).Conclusion HPV infection in women in Dalian city is dominated by high-risk types and single infection,and different age groups show different distribution characteristics of HPV genotypes,which provides a reference basis for the development of HPV prevention and control strategies in Dalian city.

Cervical cancerHuman papillomavirusInfectionGenotype

张宁宇、潘善越、马丽媛、何佳佳

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大连市第二人民医院检验科,辽宁大连 116011

宫颈癌 人乳头瘤病毒 感染 基因型

2024

标记免疫分析与临床
中国同辐股份有限公司

标记免疫分析与临床

CSTPCD
影响因子:0.978
ISSN:1006-1703
年,卷(期):2024.31(9)