The Application Value of 99Tcm-sulfur Colloid in Sentinel Lymph Node Biopsy of Breast Cancer:a Meta-analysis
Objective To evaluate the effectiveness of 99 Tcm-sulfur colloid injection in locating sentinel lymph node in breast cancer patients.Methods We searched PubMed,Embase,CNKI,Wanfang and VIP databases form the inception to December,2023 for the studies related with the use of 99Tcm-sulfur colloid injection as a tracer for SLNs in SLNB of breast cancer.Two investigators screened literature,extracted relevant data and assessed the quality of the literatures independently.The meta-analysis was performed using R 4.1.3 software.The publication bias was assessed by the funnel plot.Results A total of 18 studies were included for the final analysis,consisting of 1,926 breast cancer patients.The result of the meta-analysis showed that 99Tcm-sulfur colloid in SLNs had the detection rate 97.88％(95％CI 0.9663-0.9868),sensitivity 84.19％(95％CI 0.6752-0.9317),specificity 97.80％(95％CI 0.9164-0.9945),and the false negative rate 8.32％(95％CI 0.0377-0.1736).The subgroup analysis showed that the detection rate of 99Tcm-sulfur colloid for intradermal injection was 98.74％(95％CI 0.9768-0.9932),which was higher than subcutaneous injection 96.83％(95％CI 0.9566-0.9770).The detection rates of SLNs reported in the 18 articles were used to assess publication bias,and the funnel plot showed that a low possibility of publication bias.Conclusion The tracer method of 99Tcm-sulfur colloid could have a high clinical value in SLNB of breast cancer.
Breast cancerSentinel lymph node biopsyRadioisotopes99Tcm-sulfur colloidMeta-analysis
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