The Combined Value of Body Temperature,IL-2R,PT and LDL-C in the Differential Diagnosis of Young Ischemic Moyamoya Disease Patients
Objective To evaluate the value of clinical baseline data,basic signs and routine laboratory tests in the differential diagnosis of young patients with Moyamoya disease(MMD).Methods The basic signs,25 laboratory tests and clinical baseline data of 43 cases of ischemic,34 cases of hemorrhagic and 31 cases of asymptomatic MMD inpatients in the Department of Neurology of Beijing Tiantan Hospital of Capital Medical University were retrospectively analyzed.The differences of various indicators among different clinical types of young MMD patients were identified and evaluated.The influence and differential diagnostic performance were investigated by using receiver operating characteristic curve and multiple logistic regression analysis.Results The body temperature,SBP,DBP,IL-2R,GLU,B-WBC and B-NEUT were higher in young ischemic MMD patients,while PT,CHO,HDL-C and LDL-C were lower.B-WBC,B-NEUT,LDH were lower,CHO and LDL-C were higher in young hemorrhagic MMD patients.All differences above were statistically significant(P＜0.05).Body temperature and IL-2R were risk factors(P＜0.05),and PT and LDL-C were protective factors for ischemic events in young MMD(P＜0.05).LDH was a protective factor for hemorrhagic events(P＜0.05).AUC of the combined diagnostic model of body temperature,IL-2R,PT and LDL-C was 0.762,with the sensitivity of 77.50％,and the specificity of 63.33％.Conclusion The elevated body temperature serum level of IL-2R,along with the decreased serum level of PT and LDL-C,are closely related to the occurrence of ischemic events in young MMD patients.The combined diagnostic model can effectively distinguish the ischemic young MMD patients with other clinical types.
万方数据
维普
