Clinical Values of CA15-3,TPS Combined with SPECT Radionuclide Bone Imaging in the Diagnosis of Bone Metastasis of Breast Cancer
Objective To explore the diagnostic value of serum carbohydrate antigen 15-3(CA15-3)level,serum tissue polypeptide specific antigen(TPS)level and SPECT/CT radionuclide bone imaging in patients with bone metastases from breast cancer.Methods 70 patients with breast cancer who were hospitalized for the examination and treatment were sampled for this study,including 30 patients with bone metastasis as observation group A,40 patients without bone metastasis as observation group B,and 70 healthy people who were hospitalized for physical examination during the same period as the control group.All subjects were diagnosed by CA15-3 and TPS combined with SPECT radionuclide bone imaging,respectively,and the clinical significance of the individual and combined diagnosis of the three indicators was evaluated.Results Levels of CA15-3 and TPS in group A were significantly higher than those in group B and control group(P＜0.05);Among 70 cases of breast cancer,30 cases of bone metastasis were pathologically confirmed,including 10 cases of single bone metastasis,20 cases of multiple bone metastasis,7 cases of chest/clavicle,10 cases of spine,5 cases of ribs and 8 cases of pelvis.The sensitivity,specificity and accuracy of CA15-3,TPS combined with SPECT radionuclide bone imaging were higher than those of single-marker tests(P＜0.05);Compared with normal bone tissue,ADC values of metastatic lesions in chest/clavicle,spine,ribs and pelvis were significantly different between groups(P＜0.05).Conclusion CA15-3,TPS combined with SPECT radionuclide bone imaging in the diagnosis of bone metastasis of breast cancer can improve the diagnostic accuracy and sensitivity,with a significant clinical significance.
Bone metastasis of breast cancerRadionuclide bone imagingSerum carbohydrate antigen 15-3Serum tissue polypeptide specific antigen
万方数据
维普
