Fibroblast activation protein(FAP),which is present on the surface of cancer associated fibroblasts,has recently become an important target for tumor imaging.Although FAP targeted positron radiopharmaceuticals have developed rapidly,99Tcm labeled drugs also show promising advantages,such as simple preparation and wide application.Therefore,the technetium(99Tcm)labeled FAPI tracers used for SPECT imaging is gradually receiving more attentions.This review categorizes the molecular structures of technetium(99Tcm)labeled FAPI radiotracers,and analyzes the structure-activity relationship of the modified groups of linkers.Furthermore,the design strategies and research progress of the 99Tcm-FAPI tracers are emphasized.A systematic summary and outlook is provided to guide the future development and transformation of FAPI-based radiopharmaceuticals for SPECT/CT imaging.
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