摘要
目的 评价婴儿接种乙型肝炎疫苗的效果.方法 回顾性分析2002-2012年北京市顺义区母亲为乙肝表面抗原(HBsAg)阳性和母亲为HBsAg阴性的婴儿(普通婴儿)接种乙肝疫苗后的血清学资料.结果 224例母亲为HBsAg阳性的婴儿中,HBsAg阳性者5例,阳性率为2.2％;HBsAb阳性者204例.219例HBsAg阴性婴儿和165例普通婴儿的HBsAb阳性率分别为93.2％和99.4％.母亲HBsAg、HBeAg双阳性者、母亲单阳性者(HBsAg阳性)及母亲HBsAg阳性、HBeAg不详者,3组的免疫效果差异无统计学意义(P＞0.05).母亲HBsAg阳性婴儿免疫效果比普通婴儿差(P＜0.01).母亲为HBsAg阳性的婴儿接种10 μg剂量进口疫苗和10 μg剂量“搭配接种方案”的免疫效果均优于5μg国产疫苗(P＜0.05).母亲HBsAg阳性是阻碍婴儿HBsAb产生的影响因素(OR=0.086,P=0.035).结论 顺义区现行乙肝免疫策略对母亲为HBsAg阳性的婴儿免疫效果较理想,但较普通婴儿效果略差.
Abstract
Objective To evaluate the effect of hepatitis B vaccine among infant population in Shunyi District.Methods Infants' serological data after hepatitis B vaccination were analyzed retrospectively from 2002 to 2012 whose mothers were HBsAg-positive or HBsAg-negative(ordinary cases).Results Among 224 infants whose mothers were HBsAg-positive,5 cases (2.2％) were HBsAg positive,204 cases were HBsAb-positive.Of the above 219 HBsAg-negative infants and 165 ordinary cases,HBsAb-positive rate was 93.2％ and 99.4％ respectively.The mother was HBsAg and HBeAg double positive,single-positive (HBsAg-positive),HBsAg-positive but HBeAg was unknown,the immune effect difference in the 3 groups was not statistically significant (P ＞ 0.05).The immune effects of infants whose mothers were HBsAg-positive were worse than those of ordinary infants (P ＜ 0.01).The immune effects of infants,whose mothers were HBsAg-positive,vaccinated 10 μg imported vaccine or 10 μg vaccine" with the vaccination program" were superior to those of 5 μg domestic vaccine (P ＜ 0.05).HBsAg-positive mother was unfavorable factor of infants producing HBsAb response (OR =0.086,P =0.035).Conclusion The current hepatitis B immunization strategies in Shunyi district have good immune effects of infants,whose mothers are HBsAg positive,but worse than those of ordinary infants.
NETL
NSTL
维普
万方数据