Effect of low-dose continuous infusion of remimazolam on sleep quality on the first night after maxillofacial surgery
Objective To explore the effect of low-dose continuous infusion of remimazolam on the quality of sleep on the first night after maxillofacial surgery.Methods A total of 80 patients with maxillofacial surgery in Plastic Surgery Hospital,Chinese Academy of Medical Sciences from August 9,2021 to August 9,2013 were selected,and were randomly divided into control group and remimazolam group,with 40 cases in each group.There was no sedative drug infusion in the control group after operation,and low-dose continuous infusion of remimazolam[0.2 mg/(kg·h)]was given in the remimazolam group on the first night after operation.The sleep time of N1,N2,N3 and rapid eye movement(REM)on the first night after operation,waking time,awakening times,sleep efficiency,adverse reactions on the first night after operation,and sedation and analgesia remedies were compared between the two groups.Results Among the 80 patients,there were 16 males and 64 females,aged from 18 to 40 years,with an average of(26.3±5.7)years.The sleep time of N1 and sleep efficiency of the remimazolam group were higher than those of the control group[177.7(108.1,262.4)min vs.90.5(70.6,131.8)min,81.3%(54.7%,96.0%)vs.68.6%(53.4%,82.8%)];the sleep time of REM and awakening times were lower than those in control group[2.3(0.0,11.1)min vs.47.1(1.6,91.1)min,6.5(2.0,12.0)times vs.26.0(18.3,43.3)times];the ratio of SpO2<90%and tachycardia in remimazolam group were higher than those in control group(70.0%vs.37.5%,95.0%vs.80.0%),and the differences were statistically significant(P<0.05).There was no significant difference between the two groups in other adverse reactions and sedative and analgesic drugs(P>0.05).Conclusions Low-dose continuous infusion of remimazolam can effectively prolong the sleep time of N1,shorten the sleep time of REM,reduce the awakenings times,improve sleep efficiency and have no serious adverse reactions.
remimazolamlow-dose continuous infusionsleep qualitymaxillofacial surgerythe first night after operationpolysomnia monitoring
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