Meta-analysis of the effectiveness of compound Kushen injection in preventing radiation induced bowel injury
Objective To explore the effectiveness of compound Kushen injection(CKI)in preventing radiation induced bowel injury(RBI),and to provide evidence-based reference for clinical use of CKI to prevent RBI.Methods The randomized controlled trial(RCT)study of CKI in preventing of RBI published by China knowledge network,Wanfang database,VIP database,PubMed and The Cochrane Library from establishment to July 20th,2023 was selected.The extracted data were analyzed by using RevMan 5.4 statistical software.Results A total of 10 literatures were included,there were 690 patients,including 355 patients in the combined group and 335 patients in the control group.Meta-analysis showed that the clinical effective rate in the combined group was higher than that in the control group,and the incidence of RBI,Grade 1 RBI and Grade 2 RBI was lower than that in the control group,and the differences were statistically significant(P<0.05).Conclusions CKI can effectively reduce the incidence of RBI and increase the clinical efficacy of patients,which is worthy of clinical promotion.
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