Analysis of peripheral blood lymphocyte subsets in patients with different cytomegalovirus infection status
Objective To explore the characteristics of peripheral blood lymphocyte subsets in patients with different cytomegalovirus(CMV)infection status.Methods A total of 139 inpatients with CMV infection in Peking Union Medical College Hospital from June 2016 to Janurary 2023 were selected,the characteristics of changes in peripheral blood lymphocyte subsets in patients with different CMV infection status were analyzed,and the multivariate logistic regression equation was used to analyze the influencing factors of CMV disease.Results Among the 139 patients,there were 68 males and 71 females,aged from 16 to 90 years,with an average age of(51.0±18.0)years.There were 72 cases of CMV disease,42 cases of subclinical CMV infection and 25 cases of latent CMV infection among the patients.The plasma CMV DNA load of patients with CMV disease group were significantly higher than those of patients with subclinical infection and latent CMV infection,and the differrences were statistical significant(P<0.05).Compared with patients with subclinical CMV infection and latent CMV infection,the number of peripheral blood lymphocytes in patients with CMV disease were significantly lower,with statistical significance(P<0.05).Multivariate logistic regression analysis results showed that patients with multiple infections(OR=9.783,95%CI:1.964-48.729,P=0.005)and increased CD8+CD38+/CD8+(OR=1.047,95%CI:1.003-1.093,P=0.034)were more likely to develop CMV disease.Conclusions There are obvious immune dysfunction in patients with CMV disease.Multiple infections and significant activation of CD8+CD38+were risk factors for CMV disease.When patients have multiple infections and CD8+CD38+/CD8+increases significantly,we need to be alert to the occurrence of CMV disease.
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