Analysis of the correlation between serum ferritin and transferrin saturation and death risk of non-anemic population
Objective To explore the correlation between serum ferritin(SF)and transferrin saturation(TSAT)and all-cause death and cardiovascular death in non-anemic general population.Methods A total of 7 167 non-anemic cases from national health and nutrition examination survey(NHANES)from 1999 to 2000 and 2001 to 2002 were selected,the end point of death was followed up before December 31,2006.Threshold effect analysis and multivariate cox regression model was used to analyze the correlation between SF and TAST and the risk of all-cause death and cardiovascular death.Results Among the 7 167 patients,there were 3 533 males and 3 634 females,aged from 18 to 85 years,with an average age of(46.1±20.0)years,with an average BMI of(27.9±6.2)kg/m2.The patients were followed up for(5.5±1.2)years with a total of 11 623 person/year,which inclued 452 all-cause deaths and 117 cardiovascular deaths.There was a nonlinear correlation between SF and all-cause death and cardiovascular death,and the cut-off value of SF was 200 ng/ml,when SF<200 ng/ml,the risk of all-cause death increased by 25%(HR=1.252,95%CI:1.068-1.486,P=0.008)and the risk of cardiovascular death increased by 37%(HR=1.370,95%CI:1.076-1.900,P=0.036)for every 100 ng/ml increase in SF.TSAT had an L-shaped correlation with all-cause mortality,and the cut-off value of TSAT was 30%,when TSAT<30%,the risk of all-cause death decreased by 21%(HR=0.791,95%CI:0.681-0.914,P=0.001)for every 10%increase in TSAT.TSAT was negatively correlated with the risk of cardiovascular death(HR=0.803,95%CI:0.660-0.963,P=0.014).Conclusions For non-anemic population,the SF value has a nonlinear correlation with all-cause death and cardiovascular death,with a cut-off value of 200 ng/ml,and TSAT value has an L-shaped correlation with all-cause death,with a cut-off value of 30%,and TSAT has a negative correlation with cardiovascular death.It is suggested that SF and TSAT in non-anemic population should be controlled in a suitable range to reduce the risk of death and improve the prognosis.
serum ferritin(SF)transferrin saturation(TSAT)all-cause deathcardiovascular deathnon-anemic population
NETL
NSTL
万方数据
