A study on the correlation between the reproductive characteristics of postmenopausal women and osteoporosis and sarcopenia in Beijing
Objective To explore the correlation between the reproductive characteristics of postmenopausal women and osteoporosis (OP) and sarcopenia in Beijing.Methods A total of 827 postmenopausal women who were permanent residents of several communities in different urban areas from September 2017 to May 2018 were selected,and were divided into non-OP group (n=488) and OP group (n=339) according to the results of bone mineral density measurement,and were divided into non-sarcopenia group (n=698) and sarcopenia group (n=129) according to the results of grip strength measurement.Their menstrual history,menopause history,pregnancy history and other related data were collected by on-site questionnaires.Serum 25(OH)D level was quantitatively measured by enzyme-linked immunosorbent assay,bone mineral density of lumbar spine and double hip joints was measured by dual-emission X-ray absorptiometry,and grip strength was measured by hand-held electronic grip strength meter.The influencing factors of OP and sarcopenia in postmenopausal women in Beijing were analyzed by multivariate logistic regression equation.Results Among 827 postmenopausal women,aged 46-85 years,with an average of (65.0±7.6) years.Among them,339 cases were OP (40.99%) and 129 cases were sarcopenia (15.60%).Multivariate logistic regression analysis showed that postmenopausal women with shorter menstrual duration (OR=0.930,95%CI:0.909-0.951,P<0.001),later menopause stage (OR=2.442,95%CI:1.964-3.307,P<0.001),more pregnancies (OR=2.335,95%CI:1.202-4.616,P=0.013),more births (OR=2.056,95%CI:1.945-2.713,P<0.001) and lower vitamin D level (OR=0.909,95%CI:0.903-0.916,P=0.001) had higher risk of OP.Postmenopausal women with more pregnancies (OR=1.309,95%CI:1.195-1.434,P<0.001),more births (OR=2.657,95%CI:2.064-3.421,P<0.001) and lower vitamin D levels (OR=0.623,95%CI:0.466-0.833,P=0.001) had higher risk of sarcopenia.Conclusions OP is common in postmenopausal women in Beijing.We should pay attention to the menstrual duration,menopause stage,pregnancy and childbirth times and vitamin D level of postmenopausal women,and do early screening to reduce or delay the occurrence of OP and sarcopenia.
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