Clinical application of low-dose esketamine combined with ciprofol in elderly patients undergoing endoscopic ultrasonography
Objectives To explore the clinical effect of low dose esketamine combined with cyclopofol in elderly patients undergoing ultrasound gastroscopy.Methods A total of 80 elderly patients who underwent painless ultrasound gastroscopy in Xuanwu Hospital,Capital Medical University from October to December 2023 were selected,and divided into esketamine combined with cyclopofol group (EC group) and sufentanil combined with cyclopofol group (SC group) by random number table method,with 40 cases in each group.The EC group was induced by intravenous esketamine 0.3 mg/kg and cypofol 0.3 mg/kg,the SC group was induced by intravenous sufentanil 0.1 μg/kg and cypofol 0.3 mg/kg,and the two groups were maintained by continuous infusion of cypofol.The general condition,intraoperative hypotension and postoperative adverse reactions were compared between the two groups.Results Among the 80 patients,there were 32 males and 48 females,aged from 65 to 79 years,with an average of (70.1±2.8) years.Compared with SC group,the incidence of intraoperative hypotension (7.5% vs.30.0%),bradycardia (7.5% vs.35.0%),respiratory depression (2.5% vs.20.0%) and vasoactive drug use rate (12.5% vs.52.5%) were lower in EC group.The incidence of postoperative hypotension was lower (5.0% vs.22.5%),and the dosage of cyclopofol was lower[(28.3±4.9) mg vs.(34.9±5.0) mg],with statistical significance (P<0.05).Conclusions Low-dose esketamine 0.3 mg/kg combined with ciprofol is safe and effective for elderly patients undergoing endoscopic ultrasonography with more stable circulation in perioperative period.
万方数据
维普
