Etiology of cerebellar ataxia in children and clinical characteristics of acute post-infectious cerebellar ataxia after gastrointestinal surgery
Objective To explore the etiology of cerebellar ataxia (CA) in children and the clinical characteristics of acute post-infectious cerebellar ataxia (APCA) after gastrointestinal surgery.Methods A total of 428 children with in Children's Hospital Affiliated to Capital Institute of Pediatrics from January 2007 to January 2023 were selected,and the etiology of CA and clinical characteristics of APCA after gastrointestinal surgery were analyzed.Results Among the 428 cases,there were 251 males and 177 females,aged from 0.8 years to 13 years,with an average of (4.3±2.1) years.The main etiology were APCA (349 cases,81.54%),acute cerebellar encephalitis (15 cases,3.50%),and hereditary metabolic CA (13 cases,3.04%).Among the 349 cases of APCA,181 patients had a history of gastrointestinal surgery,while there were no cases of CA with other causes with a history of gastrointestinal surgery.The onset time of APCA after gastrointestinal surgery ranged from 0.8 to 2.6 years after the surgery.Compared with APCA patients without a history of gastrointestinal surgery,patients with a history of gastrointestinal surgery had a higher proportion of males,a younger age,a shorter duration of ataxia,a lower proportion of immunotherapy,and a higher recurrence rate,and the differences were statistically significant (P<0.05).There were 56 cases of recurrence (13.08%) among the APCA patients,of which 42 cases (75.00%) had a history of gastrointestinal surgery.Conclusions There are many etiology of CA,so differential diagnosis should be made in clinical diagnosis and treatment.APCA is the most common etiology.Children with a history of gastrointestinal surgery are more likely to have recurrent disease,but the prognosis is good.
万方数据
维普
