Correlation between serum IL-33,neuregulin-1 and cognitive impairment in patients with Parkinson's disease
Objective To explore the correlation between IL-33,neuregulin-1(NRG1)and cognitive impairment(PI)in patients with Parkinson's disease(PD).Methods A total of 115 PD patients admitted in Handan Hospital of Traditional Chineses from September 2021 to September 2023 were selected,and were divided into non-CI group(CI≥26 score,69 cases)and CI group(<26 score,46 cases)according to the Montreal cognitive assessment scale(MoCA)score.Serum levels of IL-33 and NRG1 were detected by enzyme-linked immunosorbent assay(ELISA).Spearman was used to analyze the correlation between serum IL-33,NRG1 and scores of MoCA and unified Parkinson's disease rating scale Ⅲin PD patients,and multivariate logistic regression equation was applied to analyze the influencing factors of CI in PD patients.Results Among the 115 patients,there were 68 males and 47 females,aged from 45 to 80 years,with a mean age of(65.3±8.5)years.The levels of serum IL-33 and NRG1 in PD patients were negatively correlated with MoCA scores(r=-0.472,-0.601,both P<0.001),and positively correlated with UPDRS Ⅲ score(r=0.654,0.739,both P<0.001).The results of the multivariate results showed that PD patients with higher age(OR=2.694,95%CI:1.242-5.843,P=0.012),lower years of education(OR=0.706,95%CI:0.544-0.916,P=0.000),higher serum levels of IL-33(OR=3.528,95%CI:1.389-8.968,P=0.008),and higher serum levels of NRG1(OR=2.831,95%CI:1.382-5.801,P=0.004)were more likely to develop CI.Conclusions The serum levels of IL-33 and NRG1 levels are significantly elevated in PD patients,which are closely associated with the development of CI,and the risk of CI could be assessed by dynamically monitoring the levels of IL-33 and NRG1 in PD patients.
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