Analysis of the influencing factors of vestibular migraine in menopausal female
Objective To explore the influencing factors of vestibular migraine(VM)in menopausal female and its correlation with estradiol and calcitonin gene-related peptide(CGRP).Methods A total of 100 menopausal female patients with VM(menopausal VM group)in Affiliated Hospital of Shandong Second Medical University from March,2022 to February,2024 were selected,and 100 menopausal healthy physical examination subjects(menopausal control group)were selected.The influencing factors of VM in menopausal female was analyzed by logistic regression,and the correlation between estrogen CGRP levels and VM in menopausal female was analyzed by Pearson correlation coefficient.Results The age of 200 patients ranged from 41 to 59 years,with an average of(49.0±4.9)years.Compared with the menopausal control group,the serum estradiol level in the menopausal VM group was significantly decreased[(39.13±5.32)pg/ml vs.(81.94±5.98)pg/ml],and the CGRP level in the menopausal VM group was significantly increased[(88.47±8.45)pg/ml vs.(59.59±5.97)pg/ml],and the differences with statistically significant(P<0.05).Multifactorial logistic regression analysis showed that menopausal female with lower levels of estradiol(OR=0.559,95%CI:0.189-0.809,P=0.003)and higher levels of CGRP(OR=7.601,95%CI:2.193-14.348,P=0.001)were more likely to develop VM.Pearson analysis results showed that the frequency and duration of migraine and vertigo attacks were negatively correlated with estradiol levels,and positively correlated with CGRP levels(P<0.05).Conclusions Serum estradiol levels decrease and CGRP levels increase in menopausal female VM,which are independent risk factors for VM in menopausal female.The frequency and duration of migraine and vertigo are negatively correlated with estradiol levels,and positively correlated with CGRP levels.
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