Analysis of detection of HBV infection-related biomarkers in blood donors from 17 blood centers of China from 2016 to 2022
Objective To explore the HBV infection of blood donors in 17 provincial capital cities in China,and to provide reference for the management of safe blood donors.Methods A total of 17 blood centers in China were selected,and the blood screening results from 2016 to 2022 of hepatitis B surface antigen(HBsAg)and hepatitis B virus nucleic acid(HBV DNA)detection of blood donors were collected,and the HBsAg unqualified rates and annual trends among first-time blood donors and repeated blood donors,correlation of HBsAg unqualified results between first-time and repeated blood donors,unqualified results of HBV DNA in HBsAg non reactive donors(HBsAg-/HBVDNA+)and HBV unqualified rate among the total blood donors were statistically analyzed;the overall HBV unqualified rate of blood donors from 17 blood centers in different regions was further calculated and analyzed.Results From 2016 to 2022,the HBsAg unqualified rate of first-time blood donors in 17 blood centers was 59.60/10 000(1.6/10 000-142.85/10 000),while that of repeated blood donors was 16.67/10 000(0.60/10 000-48.68/10 000).The unqualified rate of HBV DNA in non reactive HBsAg donors was 6.69/10 000(1.30/10 000-17.57/10 000).The overall HBV unqualified rate among all blood donors was 47.06/10 000(3.46/10 000-103.78/10 000),and the differences among the above four unqualified rates were statistically significant(P<0.05).The overall unqualified rate of HBV among blood donors in the eastern region(34.04/10 000)was lower than that in the central region(50.42/10 000)and the western region(52.07/10 000),and the differences among blood donors in the three regions were statistically significant(P<0.05).Conclusions The HBsAg unqualified rates of first-time blood donors and repeat blood donors in 17 provincial capital cities have shown an overall downward trend with time.Repeated blood donors are relatively safe blood donors.HBV DNA testing can further reduce the risk of HBV transmission through blood.The distribution of HBV infection among blood donors is regional,and the unqualified rate of HBV among blood donors in the eastern region is significantly lower than that in the central and western regions,which is consistent with the distribution of the general population.
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