The predictive value of inflammatory factors and coagulation function on abdominal infection in patients with liver cirrhosis ascites
Objective To explore the predictive value of inflammatory factors and coagulation function on abdominal infection in patients with liver cirrhosis ascites.Methods A total of 82 patients with liver cirrhosis ascites in Beijing You'an Hospital,Capital Medical University from January to May 2024 were selected,and were divided into infected group(n=45)and uninfected group(n=37)according to whether abdominal infection occurred.The inflammatory factors and coagulation function were compared between the two groups,and the correlation between inflammatory factors,coagulation function and abdominal infection was analyzed by Spearman correlation.The influencing factors of abdominal infection in patients with liver cirrhosis ascites was analyzed by multivariate logistic regression.The predictive value of inflammatory factors and coagulation function in patients with liver cirrhosis ascites was evaluated by ROC curve.Results Among the 82 patients,there were 69 males and 12 females,aged from 33 to 82 years,with an average of(59.2±11.5)years.There were 45 patients of abdominal infection,and the abdominal infection rate was 54.88%.Spearman correlation analysis showed that abdominal infection was positively correlated with CRP,procalcitonin(PCT),INR and D-dimer(DD).Multivariate logistic regression analysis showed that patients with the higher CRP(OR=4.701,95%CI:1.040-21.253,P=0.044),the higher PCT(OR=4.800,95%CI:1.481-15.558,P=0.009),the higher INR(OR=8.373,95%CI:1.088-64.462,P=0.041)and higher DD(OR=3.441,95%CI:1.045-11.327,P=0.042)were more likely to have abdominal infection.ROC curve analysis showed that the AUC of CRP,PCT,INR and DD in predicting abdominal infection in patients with liver cirrhosis ascites were 0.759(95%CI:0.655-0.863,P=0.000),0.756(95%CI:0.648-0.864,P=0.000),0.636(95%CI:0.513-0.757,P=0.036),0.659(95%CI:0.541-0.778,P=0.014),with sensitivity of 0.8667,0.7778,0.7556 and 0.5111,specificity of 0.5405,0.7027,0.4865 and 0.8378,respectively.Conclusions Inflammatory factors and coagulation function have high predictive value for abdominal infection in patients with liver cirrhosis ascites,and provide important reference for clinical treatment.
liver cirrhosis ascitesabdominal infectioninflammatory factorscoagulation function
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