首页|合并自发性细菌性腹膜炎对男性酒精性肝硬化患者能量代谢的影响

合并自发性细菌性腹膜炎对男性酒精性肝硬化患者能量代谢的影响

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目的 探讨合并自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)对男性酒精性肝硬化(alcoholic liver cirrhosis,ALC)患者能量代谢的影响.方法 选取2018年1月至2023年6月首都医科大学附属北京佑安医院男性ALC患者85例,根据是否合并SBP分为SBP组(n=34)和无SBP组(n=51).对所有患者进行间接能量代谢测定,收集能量代谢指标,包括实测静息能量消耗(resting energy expenditure,REE)、预测静息能量消耗(predict resting energy ex-penditure,pREE)、呼吸商(respiratory quotient,RQ)、碳水化合物氧化率(carbohydrate oxidation rate,CHO%)、脂肪氧化率(fat oxidation rate,FAT%)及蛋白质氧化率(protein oxidation rate,PRO%),并对患者进行血常规及肝功能测定.比较两组ALT、AST、T-BIL、ALB、REE、pREE、REE/pREE、RQ、CHO%、FAT%及PRO%,采用单因素分差分析比较无腹水组、少量腹水组、中量腹水组及大量腹水组REE、pREE、REE/pREE、RQ、CHO%、FAT%及PRO%.结果 85例ALC患者年龄30～63岁,平均(51.5±7.8)岁.SBP组ALB[(30.93±5.49)g/L比(34.00±5.42)g/L]、前白蛋白[(102.13±39.60)g/L比(136.00±67.65)g/L]、Hb[(105.47±24.44)g/L比(117.76±26.17)g/L]低于无SBP组;SBP组REE/pREE[(106.00±16.37)%比(95.41±13.00)%]、FAT%[(50.59±14.92)%比(44.20±12.13)%]高于无SBP组,RQ[(0.78±0.05比0.80±0.05)]低于无SBP组;大量腹水组REE/pREE高于少量腹水组、中量腹水组[(107.57±17.11)%比(96.46±14.98)%、(96.73±13.93)%],差异均有统计学意义(P<0.05).结论 SBP及腹水量均可影响ALC患者的能量代谢,合并SBP可提高ALC患者的REE/pREE及FAT%,降低RQ值.
Effect of spontaneous bacterial peritonitis on energy metabolism in male patients with alcoholic liver cirrhosis
Objective To explore the influence of spontaneous bacterial peritonitis(SBP)on the energy metabolism of male patients with alcoholic liver cirrhosis(ALC).Methods A total of 85 male ALC patients in Beijing You'an Hospital,Capital Medical University from January 2018 to June 2023 were selected,and were divided into the SBP group(n=34)and the non-SBP group(n=51)based on the presence or absence of SBP.Indirect energy metabolism was measured for all patients,and energy metabolism indicators were collected,including resting energy expenditure(REE),predicted resting energy expenditure(pREE),respiratory quotient(RQ),carbohydrate oxidation rate(CHO%),fat oxidation rate(FAT%),and protein oxidation rate(PRO%).Blood routine tests and liver function tests were conducted for all patients.The levels of ALT,AST,T-BIL,ALB,REE,pREE,REE/pREE,RQ,CHO%,FAT%,and PRO%were compared between the two groups.The REE,pREE,REE/pREE,RQ,CHO%,FAT%,and PRO%were compared among the groups without ascites,with a small amount of ascites,with a moderate amount of ascites,and with a large amount of ascites by one-way analysis of variance.Results The 85 patients with ALC ranged in age from 30 to 63 years,with an average age of(51.5±7.8)years.The levels of ALB[(30.93±5.49)g/L vs.(34.00±5.42)g/L],prealbumin[(102.13±39.60)g/L vs.(136.00±67.65)g/L],and Hb[(105.47±24.44)g/L vs.(117.76±26.17)g/L]in the SBP group were lower than those in the non-SBP group.The REE/pREE[(106.00±16.37)%vs.(95.41±13.00)%]and FAT%[(50.59±14.92)%vs.(44.20±12.13)%]in the SBP group were higher than those in the non-SBP group,while the RQ[(0.78±0.05)vs.(0.80±0.05)]was lower than that in the non-SBP group.The REE/pREE in the large amount of ascites group was higher than those in the small and moderate amount of ascites groups[(107.57±17.11)%vs.(96.46±14.98)%,(96.73±13.93)%],and the differences were statistically significant(P<0.05).Conclusions Both SBP and the amount of ascites can affect the energy metabolism of ALC patients.SBP can increase the REE/pREE and FAT%and decrease the RQ value in ALC patients.

alcoholic liver cirrhosis(ALC)spontaneous bacterial peritonitis(SBP)ascitesresting energy expenditure(REE)

赵娟、苏璇、徐斌

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100069 首都医科大学附属北京佑安医院肝病中心二科

酒精性肝硬化 自发性细菌性腹膜炎 腹水 静息能量消耗

2024

10.15932/j.0253-9713.2024.10.004

北京医学
中华医学会北京分会

北京医学

CSTPCD
影响因子：0.714
ISSN：0253-9713
年,卷(期)：2024.46(10)