29855例儿科患者血小板抗体检测结果分析
Analysis of platelet antibody detection results in 29 855 pediatric patients
邵华 1甄自达 1马曙轩1
作者信息
- 1. 100045 国家儿童医学中心 首都医科大学附属北京儿童医院输血科
- 折叠
摘要
目的 探讨儿科患者中血小板抗体的产生、分布情况及其影响因素.方法 选取2019-2023年首都医科大学附属北京儿童医院进行血小板抗体检测的患儿29 855例,通过固相凝集法检测血清中血小板抗体,分析儿科患者中血小板抗体的产生、分布情况及其影响因素.结果 29 855例儿科患者中,男16 370例,女13 485例,年龄0～17岁,平均(5.7±4.9)岁.其中血小板抗体阳性患儿共2 594例,总体阳性率为8.7%.有输血史患儿血小板抗体阳性率高于无输血史患儿(14.2%比6.6%),红细胞不规则抗体筛查阳性患儿血小板抗体阳性率高于阴性患儿(14.7%比8.6%),0～4岁患儿血小板抗体阳性率高于＞4～17岁患儿(11.0%比5.6%);不同疾病种类间血小板抗体阳性率的比较,差异有统计学意义(P＜0.05).不同性别、血型血小板抗体阳性率的比较,差异均无统计学意义(P＞0.05).结论 有输血史、红细胞不规则抗体阳性、0～4岁患儿中血小板抗体阳性率较高,患有免疫系统疾病、血液或造血器官疾病、感染性疾病或寄生虫病的患儿血小板抗体阳性率较高.
Abstract
Objective To explore the production,distribution and influencing factors of platelet antibodies in pediatric patients.Methods A total of 29 855 children who underwent platelet antibody testing in Beijing Children's Hospital,Capital Medical University from 2019 to 2023 were selected,and platelet antibodies in serum were detected by solid-phase agglutination.The production,distribution and influencing factors of platelet antibodies in pediatric patients were analyzed.Results Among the 29 855 pediatric patients,there were 16 370 males and 13 485 females,aged from 0 to 17 years,with an average of(5.7±4.9)years.A total of 2 594 children were positive for platelet antibodies,with an overall positive rate of 8.7%.The positive rate of platelet antibodies in children with a history of blood transfusion was higher than that in children without a history of blood transfusion(14.2%vs.6.6%),the positive rate of platelet antibodies in children screened positive for erythrocyte irregularity antibodies was higher than that in children negative(14.7%vs.8.6%),and the positive rate of platelet antibodies in children aged 0-4 years was higher than that in children aged>4-17 years(11.0%vs.5.6%).Comparison of positive rate of platelet antibody among different diseases were statistically different(P<0.05).Conclusions Platelet antibody positivity is higher in children with a history of blood transfusion,positive erythrocyte irregularity antibodies,aged 0-4 years,and in children with immune system disorders,with disorders of blood or hematopoietic organs,and infectious diseases.
关键词
儿科/血小板抗体/输血/ABO血型Key words
pediatrics/platelet antibodies/blood transfusion/ABO blood groups引用本文复制引用
出版年
2024
NETL
NSTL
万方数据