Analysis of platelet antibody detection results in 29 855 pediatric patients
Objective To explore the production,distribution and influencing factors of platelet antibodies in pediatric patients.Methods A total of 29 855 children who underwent platelet antibody testing in Beijing Children's Hospital,Capital Medical University from 2019 to 2023 were selected,and platelet antibodies in serum were detected by solid-phase agglutination.The production,distribution and influencing factors of platelet antibodies in pediatric patients were analyzed.Results Among the 29 855 pediatric patients,there were 16 370 males and 13 485 females,aged from 0 to 17 years,with an average of(5.7±4.9)years.A total of 2 594 children were positive for platelet antibodies,with an overall positive rate of 8.7%.The positive rate of platelet antibodies in children with a history of blood transfusion was higher than that in children without a history of blood transfusion(14.2%vs.6.6%),the positive rate of platelet antibodies in children screened positive for erythrocyte irregularity antibodies was higher than that in children negative(14.7%vs.8.6%),and the positive rate of platelet antibodies in children aged 0-4 years was higher than that in children aged>4-17 years(11.0%vs.5.6%).Comparison of positive rate of platelet antibody among different diseases were statistically different(P<0.05).Conclusions Platelet antibody positivity is higher in children with a history of blood transfusion,positive erythrocyte irregularity antibodies,aged 0-4 years,and in children with immune system disorders,with disorders of blood or hematopoietic organs,and infectious diseases.
pediatricsplatelet antibodiesblood transfusionABO blood groups
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