Effect of BMI on embryonic development and pregnancy outcome of patients with preimplantation genetic testing for aneuploidies
Objective To explore the influence of BMI on embryonic development and pregnancy outcome after frozen blastocyst transfer(FBT)in patients with preimplantation genetic testing for aneuploidies(PGT-A).Methods A total of 511 patients who underwent PGT-A in the Assisted Reproductive Medicine Center of Department of Obstetrics and Gynecology,the Sixth Medical Center of Chinese PLA General Hospital were selected from January 2018 to September 2022,and the cycle data of the patients intracytoplasmic sperm injection(ICSI)were collected.The cases were divided into non-elderly group(<35 years old)and elderly group(≥35 years old)according to the age,and each group were divided into normal BMI group(18.5 kg/m2≤BMI＜24 kg/m2)and high BMI group(BMI≥24 kg/m2)according to prepregnancy BMI.The effects of high BMI in non-elderly and elderly patients on normal fertilization rate,D3 quality embryo rate,blastocyst formation rate,quality blastocyst rate,blastocyst euploidy rate,and pregnancy outcome after transplantation of euploid blastocysts were compared.Multivariate unconditional logistic regression equation was used to analyze the influencing factors of high quality blastocysts.Results The age of 511 patients ranged from 22 to 47 years,with an average age of(36.5±4.3)years.BMI ranged from 18.5 to 35.2 kg/m2,with an average BMI of(22.6±2.8)kg/m2.There were 158 cases in non-elderly group,including 129 cases in normal BMI group and 29 cases in high BMI groupm while there were 353 cases in the elderly group,including 258 cases in normal BMI group and 95 cases in high BMI group.Multivariate logistic regression analysis showed that BMI of female and male had no significant effect on high-quality blastocysts,and non-elderly women(OR=1.652,95%CI=1.504-1.843,P<0.05)were more likely to produce high-quality blastocysts.Compared with the normal BMI group,the abortion rate in the high BMI group was higher after the whole blastocyst transplantation(16.7%vs.8.2%in non-elderly group while 19.4%vs.9.4%in elderly group),but the differences were not statistically significant(P>0.05).Conclusions High BMI has no significant effect on embryonic development and pregnancy outcome of non-elderly or elderly PGT-A patients before implantation.However,patients with higher BMI should control their weight to avoid possible risk of miscarriage.
preimplantation genetic testing for aneuploidies(PGT-A)BMIembryonic developmentfrozen blastocyst transfer(FBT)miscarriageelderly
万方数据
维普
