Clinical effect evaluation on the treatment of chronic heart failure using Xiefei Lishui Mixture
Objective To evaluate the clinical effect of Xiefei Lishui Mixture in the treatment of chronic heart failure of qi and blood deficiency,blood stagnation and yang deficiency and water overflowing.Methods 99 patients,who were admitted to the Cardiology Ward,Beijing Hospital of Traditional Chinese Medicine affiliated to the Capital Medical University and the Cardiology Ward of Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from January 2020 to June 2022,were divided into control group(50)and observation group(49)by the random number method.The control group was routinely treated with western medicine according to the guidelines combined with oral Chinese medicine placebo,100 mL each time,twice a day after breakfast and dinner;and the observation group was routinely treated with western medicine according to the guidelines combined with hospital preparations of Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University number 4,100 mL each time,twice a day with warm temperature.and the course of both groups was 6 weeks.Serum Serum n-terminal pro-brain natriuretic peptide(NT-proBNP)levels and cardiac function before and after treatment[Cardiac output(Cardiac output,CO),left ventricular ejection fraction(Left Ventricular Eject Fraction,LVEF),stroke output(Stroke volume,SV),left ventricular end-diastolic volume(Left ventricular end diastolic volume,LVEDV),Left ventricular end-systolic volume(left ventricular end-systolic volume,LVESV),Ratio of peak flow rate(E/A)],frequency of re-hospitalization,adverse events and efficacy were compared between the two groups before and after the treatment.Results After 2 and 6 weeks of treatment,the serum NT-proBNP levels in both groups were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).After 2 and 6 weeks of treatment,there were significant differences in LVEDV,LVEV,LVEF,E/A and SV between the observation group and the control group(P<0.05).After 6 weeks of treatment,the CO in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).Six months after treatment through follow-up,two patients(4.3%)in the observation group were hospitalized again,which was less than that in the control group(8 cases(17.0%)),and the difference was statistically significant(P<0.05).There were 1 and 2 cases of ventricular arrhythmia and 4 and 6 cases of hypotension in the observation group and the control group,respectively,with no statistical significance(P>0.05).There were no drug-induced sudden death,abnormal urine and stool routine,drug-induced liver and kidney damage and abnormal glucose in both groups.Conclusion Conventional treatment of western medicine combined with Xiefei Lishui Mixture no.4 could reduce the serum NT-proBNP in patients with qi deficiency,blood stasis with Yang deficiency and water overflowing in chronic heart failure,improve cardiac function,reduce the frequency of hospitalization with better effect than the simple routine treatment of western medicine,and there is no increase in adverse events.
Chronic heart failureQi deficiency and blood stasisYang deficiency and water overflowingXiefei Lishui Mixturecardiac function
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