204例社区获得性肺炎患者中医证素特征及其与病程的相关性研究
A study of the characteristics of TCM pattern elements in 204 patients with community-acquired pneumonia and their correlation with disease course
张妍 1张茹 1王嘉伟 1梁枫荻 2张京轩 2周滔3
作者信息
- 1. 北京中医药大学 北京 100029
- 2. 北京中医药大学 北京 100029;北京中医药大学东方医院
- 3. 北京中医药大学东方医院
- 折叠
摘要
目的 探讨社区获得性肺炎(CAP)患者中医证素特征及其与病程的相关性.方法 采集 204 例CAP 患者的一般资料、中医四诊信息,按照"证候辨证素量表"各症状对应的证素积分,将每个证候所提示的相同证素权值进行加权求和.结果 204 例患者中,证素积分≥70的病位证素共 13 个,表证素和肺证素频次最高,分别为 163 次(占 79.9%)和 95 次(占46.6%).证素积分≥70 的病性证素共 13 个,前 3 位分别是外风证素(89 次,占 46.3%)、热证素(43 次,占 21.1%)和寒证素(32 次,占 15.7%).病位证素中,表证素在不同病程的分布,差异具有统计学意义(χ2 =22.715,P＜0.05).病性证素中,寒证素在不同病程的分布,差异具有统计学意义(P＜0.05).病位证素中,表证素、肺证素以Ⅰ级(轻度病变)、Ⅱ级(中度病变)为主,心证素以Ⅰ级(轻度病变)为主.病性证素中,外风证素、热证素、寒证素、湿证素、痰证素均以Ⅰ级(轻度病变)为主.表证素等级与病程的相关性具有统计学意义,似然比检验结果χ2 =31.759(P＜0.05).结论 CAP 患者中医证素分布具有一定的特征,表证素、寒证素与病程有显著相关性.
Abstract
Objective To investigate the characteristics of TCM pattern elements and their correlation with the course of disease in patients with community-acquired pneumonia(CAP).Methods General data and the information of the TCM four diagnoses were collected from 204 patients with CAP.The Pattern Differentiation Element Scale was employed to assign weights to symptom-associated pattern elements,subsequently computing the cumulative scores for each identified pattern.Results In the 204 patients,13 disease location elements exhibited a pattern element score of≥70,with the highest frequencies observed for exterior pattern elements and lung pattern elements,accounting for 163 times(79.9%)and 95 times(46.6%),respectively.Additionally,13 disease nature pattern elements scored≥70,with the top three being external wind pattern elements(89 times,46.3%),heat pattern elements(43 times,21.1%)and cold pattern elements(32 times,for 15.7%).Significant differences were noted in the distribution of exterior-related elements across distinct(χ2 = 22.715,P＜0.05).Notably,the distribution of cold pattern elements exhibited significant variation across different disease courses(P＜0.05).The exterior and lung pattern elements predominantly displayed grade I(mild lesions)and grade Ⅱ(moderate lesions),while the heart pattern elements were mainly grade I(mild lesions).The external wind pattern element,heat pattern element,cold pattern element,wet pattern element,and phlegm pattern element were all grade I(mild lesions).The correlation between the grade of exterior elements and the course of the disease was statistically significant,and the likelihood ratio test result was χ2 = 31.759(P＜0.05).Conclusion The distribution of TCM pattern elements in CAP patients exhibits certain characteristics,and there is a significant correlation between exterior elements and cold pattern elements and the course of the disease.
关键词
社区获得性肺炎/证素/病程Key words
community-acquired pneumonia/pattern elements/disease course引用本文复制引用
基金项目
国家重点研发计划(2018YFC1704100)
国家重点研发计划(2018YFC1704102)
全国中医(临床、基础)优秀人才研修项目(第四批)(国中医药人教发[2017]24号)
北京市卫生系统高层次卫生技术人才培养计划(2015-3-114)
出版年
2024
国家科技期刊平台
NSTL
万方数据