现代中医临床2024,Vol.31Issue(2) :83-87.DOI:10.3969/j.issn.2095-6606.2024.02.018

"石菖蒲-远志"防治痴呆探析

Shichangpu-Yuanzhi in the prevention and treatment of dementia:an analysis

贾岳津 马培 吴柔燕 刘鑫雨 付宏宇 齐欣 胡天时 刘金瑛 李志更 岳利峰
现代中医临床2024,Vol.31Issue(2) :83-87.DOI:10.3969/j.issn.2095-6606.2024.02.018

"石菖蒲-远志"防治痴呆探析

Shichangpu-Yuanzhi in the prevention and treatment of dementia:an analysis

贾岳津 1马培 2吴柔燕 1刘鑫雨 1付宏宇 3齐欣 1胡天时 1刘金瑛 1李志更 4岳利峰1
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作者信息

  • 1. 北京中医药大学东直门医院 北京 100700
  • 2. 中国医学科学院药用植物研究所
  • 3. 北京市东城区第一人民医院
  • 4. 中国中医科学院中医基础理论研究所
  • 折叠

摘要

痴呆多见于老年人,以本虚标实为主,肾虚与痰浊是本病形成的关键性因素,治疗以补虚祛邪为主.药对是临床常见的用药形式,其中,"石菖蒲-远志"相须为用,在临床中治疗痴呆可针对其本虚标实、虚实夹杂的病因病机,攻补兼施,起到化痰开窍、交通心肾、补虚益智的作用,控制当前症状,延缓疾病进程.现代药理研究则从实验及临床等角度论证,认为石菖蒲-远志在一定程度上能调控相关蛋白及通路、改善认知功能障碍等.故在临床治疗中,谨守病机,辨证施治,灵活使用该药对,能提高临床疗效,彰显中医药防治优势.

Abstract

Dementia is prevalent among the elderly,characterized by deficiency at the root and excess in the branches.Key factors contributing to this condition include kidney deficiency and phlegm turbidity.Therefore,the primary method for the treatment focuses on tonifying deficiency and eliminating evil.Herb pairing is a common approach in the creation of formulas.Shichangpu(Rhizoma Acori Tatarinowii)and Yuanzhi(Radix Polygalae),two herbs that reinforce each other,can be used to treat dementia by targeting the complex etiology involving deficiency and excess,employing a dual-action strategy to resolve phlegm and open orifices,restore interaction between the heart and kidney,and strengthen deficiency while promoting cognitive function.This approach effectively manages current symptoms and slows down the progression of the disease.Modern pharmacological studies,conducted through experimental and clinical perspectives,suggests that the Shichangpu-Yuanzhi pair can modulate relevant proteins and pathways and improve cognitive dysfunction.Therefore,in clinical treatment,adhering to the understanding of the disease mechanism,differential diagnosis,and flexible application of this drug pairing can enhance clinical efficacy,showcasing the advantages of traditional Chinese medicine in the prevention and treatment of dementia.

关键词

石菖蒲/远志/痴呆/药对/理论

Key words

Shichangpu(Rhizoma Acori Tatarinowii)/Yuanzhi(Radix Polygalae)/dementia/herb pair/theory

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基金项目

国家自然科学基金面上项目(82174046)

中国医科院医学与健康科技创新工程项目(2021-I2M-1-031)

出版年

2024
现代中医临床
北京中医药大学

现代中医临床

CSTPCD
影响因子:0.816
ISSN:2095-6606
参考文献量24
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