扶正托脓散内调外治对慢性化脓性中耳炎正虚湿蕴证临床疗效及血清炎症因子水平的影响
Clinical efficacy of internal and external treatment with Fuzheng Tuonong Powder on chronic suppurative otitis media characterized by deficiency of healthy qi and dampness accumulation and its impact on serum inflammatory factors
曹会云 1孙麦青 2陈文明 2张康洁 1夏雪园 1张甜甜 1卫岚 1靳晓静1
作者信息
- 1. 河南中医药大学第二临床医学院 郑州 450002
- 2. 河南省中医院
- 折叠
摘要
目的 观察扶正托脓散内调外治对慢性化脓性中耳炎(CSOM)正虚湿蕴证临床疗效及血清炎症因子水平的影响.方法 将140 例CSOM患者按照随机分组法分为治疗组70 例、对照组70 例,研究期间 2 组各脱落 4 例,最终纳入研究 132 例,治疗组 66 例、对照组 66 例.治疗组采用扶正托脓散内调外治.对照组采用氧氟沙星滴耳液治疗.观察症状积分、血清炎症因子(IL-8、IL-33、PAF、TNF-α)水平变化、复发率.结果 治疗后,治疗组总有效率为 96.92%,对照组总有效率为 84.84%,治疗组总有效率高于对照组,差异具有统计学意义(P<0.05).治疗后 2组患者症状积分均较本组治疗前下降,差异具有统计学意义(P<0.05);治疗后治疗组耳流脓、听力下降、耳鸣、鼓膜穿孔、肉芽组织等症状积分下降均优于对照组,差异均有统计学意义(P<0.05).耳痛积分 2 组治疗前后比较,差异无统计学意义(P>0.05);治疗后 2 组患者IL-8、IL-33、PAF、TNF-α水平均较本组治疗前明显下降,治疗组优于对照组(P<0.05).随访半年后 2组治疗有效患者复发率分别为治疗组 4.61%、对照组 28.57%,治疗组复发率明显低于对照组,远期疗效明显,差异有统计学意义(P<0.05).2 组患者心、肝、肾功能及血尿常规未出现异常改变.结论 扶正托脓散内调外治对CSOM正虚湿蕴证具有良好的临床疗效,可减轻患者的临床症状,安全性高,复发率低,远期疗效明显.
Abstract
Objective To observe the clinical efficacy of internal and external treatment with Fuzheng Tuonong Powder(Healthy-Qi-Reinforcing and Pus-Expressing Powder)on chronic suppurative otitis media(CSOM)characterized by deficiency of healthy qi and dampness accumulation,as well as its impact on serum inflammatory factors.Methods 140 CSOM patients were randomly divided into the treatment group(n=70)and the control group(n=70).During the study,4 subjects dropped out in both groups.132 cases were eventually included in the study,with 66 in each.The treatment group received internal and external treatment with Fuzheng Tuonong Powder,while the control group was treated with ofloxacin ear drops.Changes in symptom scores,serum inflammatory factors(IL-8,IL-33,PAF,TNF-α)levels,and recurrence rates were observed.Results After treatment,the total effective rate was 96.92%in the treatment group and 84.84%in the control group,with a statistically significant difference(P<0.05).Both groups showed a significant decrease in symptom scores after treatment compared to before treatment(P<0.05).Additionally,the treatment group exhibited significantly lower scores for symptoms such as ear discharge,hearing loss,tinnitus,tympanic membrane perforation,and granulation tissue compared to the control group(P<0.05).Furthermore,the levels of serum inflammatory factors IL-8,IL-33,PAF,and TNF-α decreased significantly after treatment in both groups,with greater reductions observed in the treatment group(P<0.05).The recurrence rate after six months of follow-up was 4.61%in the treatment group and 28.57%in the control group,with the treatment group demonstrating a significantly lower recurrence rate(P<0.05).No abnormal changes in cardiac,liver,renal function,or hematuria were observed in either group.Conclusion Fuzheng Tuonong Powder demonstrates significant clinical efficacy in the treatment of CSOM characterized by deficiency-cold and dampness obstruction syndrome.It effectively alleviates clinical symptoms,exhibits high safety,and reduces the recurrence rate,thus warranting further promotion and application.
关键词
慢性化脓性中耳炎/扶正托脓散/正虚湿蕴证/内调外治/血清炎症因子水平Key words
chronic suppurative otitis media/Fuzheng Tuonong Powder/internal and external treatment/serum inflammatory factor levels引用本文复制引用
基金项目
河南省中医药科学研究专项(2018ZY2093)
河南省中医药科学研究专项(2022ZY1079)
出版年
2024
国家科技期刊平台
NSTL
万方数据