进展期腺瘤性大肠息肉不同中医证候患者肠道菌群特点的临床研究
Clinical study on intestinal flora characteristics of patients with advanced adenomatous colorectal polyps with different TCM syndromes
陈淑妮 1何海滨 1夏巧 1洪丹 1李峰 2黄红霞1
作者信息
- 1. 北京中医药大学深圳医院(龙岗)脾胃病科 深圳 518100
- 2. 北京中医药大学
- 折叠
摘要
目的 分析进展期腺瘤性大肠息肉不同证候患者肠道菌群的特点.方法 收集 2020 年 12月至2023 年 3 月于北京中医药大学深圳医院(龙岗)治疗的腺瘤性大肠息肉患者.辨别患者的中医证候并收集其粪便进行肠道菌群的检测.结果 共有 214 名患者参加了这项研究,包括进展期腺瘤107 例,普通腺瘤107 例.与普通腺瘤组患者相比,进展期腺瘤组患者肠道大肠埃希菌、葡萄球菌数量显著升高,乳杆菌和双歧杆菌数量显著降低,差异具有统计学意义(P<0.05).大肠埃希菌、葡萄球菌、乳杆菌和双歧杆菌均是普通腺瘤向进展期腺瘤转变的独立危险因素,差异具有统计学意义(P<0.05).与普通腺瘤组比较,肠道湿热证组、脾虚夹瘀证组、湿瘀阻滞证和气滞血瘀证组患者肠道大肠埃希菌、葡萄球菌数量显著升高,乳杆菌和双歧杆菌数量显著降低,差异具有统计学意义(P<0.05).与气滞血瘀证组患者相比,肠道湿热证组、脾虚夹瘀证组和湿瘀阻滞证组患者肠道大肠埃希菌、葡萄球菌数量显著升高,乳杆菌和双歧杆菌数量显著降低,差异具有统计学意义(P<0.05).与湿瘀阻滞证组患者相比,肠道湿热证组患者肠道大肠埃希菌、葡萄球菌数量显著升高,乳杆菌和双歧杆菌数量显著降低;脾虚夹瘀证组患者乳杆菌数量显著降低,差异具有统计学意义(P<0.05).与脾虚夹瘀证组患者相比,肠道湿热证组患者肠道大肠埃希菌、葡萄球菌数量显著升高,乳杆菌和双歧杆菌数量显著降低,差异具有统计学意义(P<0.05).结论 大肠埃希菌、葡萄球菌数量显著升高,乳杆菌和双歧杆菌数量显著降低是普通腺瘤向进展期腺瘤转变的危险因素.肠道菌群的失调在不同中医证候进展期腺瘤患者均有发生,且存在一定的组间差异.
Abstract
Objective To analyze the characteristics of intestinal flora in patients with advanced adenomatous colorectal polyps with different Traditional Chinese Medicine(TCM)syndromes.Methods This case-control study enrolled patients with adenomatous colorectal polyps treated at Shenzhen Hospital(Longgang)of Beijing University of Chinese Medicine from December 2020 to March 2023.The TCM syndrome types of patients were identified,and their stool samples were collected for intestinal flora analysis.Results A total of 214 patients participated in the study,including 107 with advanced adenomas and 107 common adenomas.Compared with the common adenoma group,the number of intestinal Escherichia coli and Staphylococcus in the advanced adenoma group was significantly increased,while the number of lactobacillus and Bifidobacterium was significantly decreased(P<0.05).Escherichia coli,Staphylococcus,Lactobacillus and Bifidobacterium were all independent risk factors for the transition from common adenoma to advanced adenoma(P<0.05).Compared with common adenoma group,the number of intestinal Escherichia coli and staphylococcus was significantly increased in intestinal damp-heat syndrome group,spleen deficiency with stasis syndrome group,dampness-stasis syndrome group and Qi stagnation and blood stasis syndrome group,while the number of lactobacillus and bifidobacterium was significantly decreased(P<0.05).Compared with Qi stagnation and blood stasis syndrome group,the number of intestinal Escherichia coli and staphylococcus in intestinal damp-heat syndrome group,spleen deficiency with stasis syndrome group and dampness-stasis syndrome group was significantly increased,while the number of lactobacillus and Bifidobacterium was significantly decreased(P<0.05).Compared with the dampness-stasis syndrome group,the number of Escherichia coli and Staphylococcus in intestinal damp-heat syndrome group was significantly increased,while the number of lactobacillus and Bifidobacterium was significantly decreased.The number of Lactobacillus in spleen-deficiency syndrome group was significantly decreased(P<0.05).Compared with spleen deficiency and stasis syndrome group,the number of Escherichia coli and Staphylococcus in intestinal damp-heat syndrome group was significantly increased,while the number of Lactobacillus and Bifidobacterium was significantly decreased(P<0.05).Conclusion Significant increases in Escherichia coli and Staphylococcus counts and decreases in Lactobacillus and Bifidobacterium counts are risk factors for the progression from common adenomas to advanced adenomas.The imbalance of intestinal flora occurs in patients with advanced adenomas across different TCM syndromes,with notable differences between groups.
关键词
进展期腺瘤/普通腺瘤/肠道菌群/中医证候Key words
advanced adenoma/common adenoma/intestinal flora/TCM syndrome type引用本文复制引用
基金项目
深圳市龙岗区经济与科技发展专项资金医疗卫生科技计划项目(LGWJ2021-75)
出版年
2024
国家科技期刊平台
NSTL
万方数据